Antihyperalgesia effect of BmK AS, a scorpion toxin, in rat by intraplantar injection

被引：42

作者：

Chen, B ^{[1
]}

Ji, YH ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Shanghai 200031, Peoples R China

来源：

BRAIN RESEARCH | 2002年 / 952卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Buthus martensi Karsch; BmK AS; antihyperalgesia; paw withdrawal latency; voltage-gated sodium channel;

D O I：

10.1016/S0006-8993(02)03241-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The antihyperalgesia effect of BmK AS, a novel sodium chan net-specific polypeptide modulator from Chinese scorpion venom in rats was investigated in this study. PWLs (paw withdrawal latency) were increased to 150 +/- 28, 203 +/- 34 and 250 +/- 17% of the control by administration of BmK AS (10 mu1) at the concentration of 0.001, 0.01 and 0.1 mg/ml in carrageen an-induced inflamed rats, respectively. Meanwhile, PWLs were enhanced to about 126 +/- 4, 132 +/- 4 and 140 +/- 6% of the control at the same applied concentration of BmK AS in normal rats. The results suggest that BmK AS can induce peripheral antihyperalgesia and antinociception, which probably by modulating the sodium channel on nociceptive afferent pathway. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：322 / 326

页数：5

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