Periodontitis Is Associated with Cognitive Impairment in Elderly Koreans: Results from the Yangpyeong Cohort Study

被引:42
作者
Shin, Hye-Sun [1 ]
Shin, Myung-Seop [1 ]
Ahn, Yoo-Been [1 ]
Choi, Bo-Youl [2 ]
Nam, Jung-Hyun [3 ]
Kim, Hyun-Duck [1 ,4 ]
机构
[1] Seoul Natl Univ, Dept Prevent & Social Dent, Seoul, South Korea
[2] Hanyang Univ, Dept Prevent Med, Coll Med, Seoul 133791, South Korea
[3] Hanyang Univ, Inst Mental Hlth, Coll Med, Dept Neuropsychiat, Seoul 133791, South Korea
[4] Seoul Natl Univ, Sch Dent, Dent Res Inst, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
MMSE; cognitive impairment; periodontitis; epidemiology; inflammation; INFLAMMATORY MARKERS; ALZHEIMERS-DISEASE; ORAL-HEALTH; SYSTEMIC INFLAMMATION; OLDER-ADULTS; DEMENTIA; RISK; DECLINE;
D O I
10.1111/jgs.13781
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
030301 [社会学]; 100201 [内科学];
摘要
OBJECTIVES: To investigate the association between periodontitis and cognitive impairment in elderly Koreans. DESIGN: Cross-sectional study with age-and sex-matched case-control selection. SETTING: The Yangpyeong cardiovascular cohort (YCC), a part of the Korean Genome Epidemiologic Study (KoGES), Yangpyeong, South Korea. PARTICIPANTS: Individuals with cognitive impairment (n = 65) and cognitively normal controls (n = 124) aged 60 and older from the YCC. MEASUREMENTS: Alveolar bone loss was assessed on dental panoramic radiographs to categorize the cumulative history of periodontitis (HOP) into three groups: normal, moderate periodontitis, severe periodontitis. The Mini-Mental State Examination (MMSE) was used to categorize participants as cognitively normal or cognitively impaired. Age-and sex-matched conditional logistic regression models were used for analysis. Confounders considered in the analysis were age, sex, drinking, smoking, exercise, total cholesterol, total protein, body mass index, fasting plasma glucose, intima-media thickness, hypertension medication, and depression. RESULTS: Participants with HOP were more likely to have cognitive impairment than those without (odds ratio = 2.14, 95% confidence interval = 1.04-4.41). The interaction effect of smoking and exercise on periodontitis highlighted the link. CONCLUSION: Periodontitis was independently associated with cognitive impairment after controlling for various confounders. Further longitudinal research is needed to determine whether periodontitis plays a role in cognitive decline in older adults.
引用
收藏
页码:162 / 167
页数:6
相关论文
共 30 条
[1]
Inflammation and rate of cognitive change in high-functioning older adults [J].
Alley, Dawn E. ;
Crimmins, Eileen M. ;
Karlamangla, Arun ;
Hu, Peifeng ;
Seeman, Teresa E. .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2008, 63 (01) :50-55
[2]
Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies [J].
Anstey, Kaarin J. ;
von Sanden, Chwee ;
Salim, Agus ;
O'Kearney, Richard .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 166 (04) :367-378
[3]
A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults [J].
Barnes, DE ;
Yaffe, K ;
Satariano, WA ;
Tager, IB .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2003, 51 (04) :459-465
[4]
Update of the Case Definitions for Population-Based Surveillance of Periodontitis [J].
Eke, Paul I. ;
Page, Roy C. ;
Wei, Liang ;
Thornton-Evans, Gina ;
Genco, Robert J. .
JOURNAL OF PERIODONTOLOGY, 2012, 83 (12) :1449-1454
[5]
Inflammatory proteins in plasma and the risk of dementia - The Rotterdam study [J].
Engelhart, MJ ;
Geerlings, MI ;
Meijer, J ;
Kiliaan, A ;
Ruitenberg, A ;
van Swieten, JC ;
Stijnen, T ;
Hofman, A ;
Witteman, JCM ;
Breteler, MMB .
ARCHIVES OF NEUROLOGY, 2004, 61 (05) :668-672
[6]
Global prevalence of dementia: a Delphi consensus study [J].
Ferri, CP ;
Prince, M ;
Brayne, C ;
Brodaty, H ;
Fratiglioni, L ;
Ganguli, M ;
Hall, K ;
Hasegawa, K ;
Hendrie, H ;
Huang, YQ ;
Jorm, A ;
Mathers, C ;
Menezes, PR ;
Rimmer, E ;
Scazufca, M .
LANCET, 2005, 366 (9503) :2112-2117
[7]
MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[8]
Haber J, 1994, Compendium, V15, P1004
[9]
Group of Serum Inflammatory Markers and Periodontitis-Metabolic Syndrome Coexistence in Koreans [J].
Han, Dong-Hun ;
Shin, Hye-Sun ;
Kim, Mi-Sun ;
Paek, Domyung ;
Kim, Hyun-Duck .
JOURNAL OF PERIODONTOLOGY, 2012, 83 (05) :612-620
[10]
Systemic inflammation and disease progression in Alzheimer disease [J].
Holmes, C. ;
Cunningham, C. ;
Zotova, E. ;
Woolford, J. ;
Dean, C. ;
Kerr, S. ;
Culliford, D. ;
Perry, V. H. .
NEUROLOGY, 2009, 73 (10) :768-774