Morphological change caused by loss of the taxon-specific polyalanine tract in Hoxd-13

被引：23

作者：

Anan, Keiiti ^{[1
]}

Yoshida, Nobuaki

Kataoka, Yuki

Sato, Mitsuharu

Ichise, Hirotake

Nasu, Makoto

Ueda, Shintaroh

机构：

[1] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 106, Japan

[2] Univ Tokyo, Inst Med Sci, Lab Gene Express & Regulat, Tokyo 106, Japan

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2007年 / 24卷 / 01期

关键词：

homopolymeric amino acid repeats; polyalanine tract; Hoxd-13; mouse model;

D O I：

10.1093/molbev/msl161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequence comparison of Hoxd-13 among vertebrates revealed the presence of taxon-specific polyalanine tracts in amniotes. To investigate their function at the organismal level, we replaced the wild-type Hoxd-13 gene with one lacking the 15-residue polyalanine tract by using homologous recombination. Sesamoid bone formation in knock-in mice was different from that in the wild type; this was observed not only in the homozygotes but also in the heterozygotes. The present study provides the first direct evidence that taxon-specific homopolymeric amino acid repeats are involved in phenotypic diversification at the organismal level.

引用

页码：281 / 287

页数：7

共 43 条

[1] Comparative analysis of amino acid repeats in rodents and humans [J].

Albà, MM ;

Guigó, R .

GENOME RESEARCH, 2004, 14 (04) :549-554

[2] A molecular pathogenesis for transcription factor associated poly-alanine tract expansions [J].

Albrecht, AN ;

Kornak, U ;

Böddrich, A ;

Süring, K ;

Robinson, PN ;

Stiege, AC ;

Lurz, R ;

Stricker, S ;

Wanker, EE ;

Mundlos, S .

HUMAN MOLECULAR GENETICS, 2004, 13 (20) :2351-2359

[3] Alanine tracts: the expanding story of human illness and trinucleotide repeats [J].

Brown, LY ;

Brown, SA .

TRENDS IN GENETICS, 2004, 20 (01) :51-58

[4] The mouse Hoxd13spdh mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes [J].

Bruneau, S ;

Johnson, KR ;

Yamamoto, M ;

Kuroiwa, A ;

Duboule, D .

DEVELOPMENTAL BIOLOGY, 2001, 237 (02) :345-353

[5]

CATRON KM, 1995, MOL CELL BIOL, V15, P861

[6] THE HOX-4.8 GENE IS LOCALIZED AT THE 5' EXTREMITY OF THE HOX-4 COMPLEX AND IS EXPRESSED IN THE MOST POSTERIOR PARTS OF THE BODY DURING DEVELOPMENT [J].

DOLLE, P ;

IZPISUABELMONTE, JC ;

BONCINELLI, E ;

DUBOULE, D .

MECHANISMS OF DEVELOPMENT, 1991, 36 (1-2) :3-13

[7] DISRUPTION OF THE HOXD-13 GENE INDUCES LOCALIZED HETEROCHRONY LEADING TO MICE WITH NEOTENIC LIMBS [J].

DOLLE, P ;

DIERICH, A ;

LEMEUR, M ;

SCHIMMANG, T ;

SCHUHBAUR, B ;

CHAMBON, P ;

DUBOULE, D .

CELL, 1993, 75 (03) :431-441

[8] Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease [J].

Dunah, AW ;

Jeong, H ;

Griffin, A ;

Kim, YM ;

Standaert, DG ;

Hersch, SM ;

Mouradian, MM ;

Young, AB ;

Tanese, N ;

Krainc, D .

SCIENCE, 2002, 296 (5576) :2238-2243

[9] SPECIES-SPECIFIC INTERACTION OF THE GLUTAMINE-RICH ACTIVATION DOMAINS OF SP1 WITH THE TATA BOX-BINDING PROTEIN [J].

EMILI, A ;

GREENBLATT, J ;

INGLES, CJ .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (03) :1582-1593

[10] Functional insights from the distribution and role of homopeptide repeat-containing proteins [J].

Faux, NG ;

Bottomley, SP ;

Lesk, AM ;

Irving, JA ;

Morrison, JR ;

de la Banda, MC ;

Whisstock, JC .

GENOME RESEARCH, 2005, 15 (04) :537-551

← 1 2 3 4 5 →