The mouse as a model for the effects of MHC genes on human disease

被引：35

作者：

Allcock, RJN

Martin, AM

Price, A

机构：

[1] Royal Perth Hosp, Dept Clin Immunol & Biochem Genet, Perth, WA 6000, Australia

[2] Univ Western Australia, Dept Pathol, Nedlands, WA 6009, Australia

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(00)01654-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As mice are often used to model human major histocompatibility complex (MHC)-associated diseases, if is important to understand how their MHC regions differ at the DNA level. The sequencing of the mouse MHC (H2 region) has enabled a detailed map of this region to be assembled for comparison with the human MHC. Here, Richard Allcock and colleagues outline the similarities between the human and mouse MHC regions and discuss notable differences that might affect disease models.

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页码：328 / 332

页数：5

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