Growth suppression and induction of heat-shock protein-70 by 9-cis B-carotene in cervical dysplasia-derived cells

被引：16

作者：

Toba, T

Shidoji, Y

Fujii, J

Moriwaki, H

Muto, Y

Suzuki, T

Ohishi, N

Yagi, K

机构：

[1] INST APPL BIOCHEM, MITAKA, TOKYO 50501, JAPAN

[2] GIFU UNIV, SCH MED, DEPT INTERNAL MED 1, GIFU 500, JAPAN

来源：

LIFE SCIENCES | 1997年 / 61卷 / 08期

关键词：

9-cis beta-carotene; all-trans beta-carotene; HSP70; apoptosis; chemoprevention; cervical dysplasia;

D O I：

10.1016/S0024-3205(97)00566-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of the present study was to determine to what extent 9-cis beta-carotene, one of the most abundant naturally-occurring cis-isomers of beta-carotene, can inhibit the growth of cervical dysplasia-derived cells in comparison with all-trans beta-carotene. We found that 9-cis beta-carotene was dose-dependently more effective than all-trans beta-carotene. Both carotenes induced the intracellular accumulation of heat-shock protein-70 (HSP70), and the treated cells showed morphological changes indicative of apoptosis. The results of the present study strongly suggest that the induction of HSP70 by beta-carotene might be involved in beta-carotene-mediated suppression of the cell growth through apoptosis.

引用

页码：839 / 845

页数：7

共 16 条

[1]

BOONE CW, 1992, CANCER RES, V52, P1651

[2]

JENSEN CD, 1987, NUTR REP INT, V35, P413

[3]

Kizaki M, 1996, BLOOD, V87, P1977

[4]

KRINSKY NI, 1993, ANNU REV NUTR, V13, P561, DOI 10.1146/annurev.nutr.13.1.561