Practical synthesis of 1,3-diaryl-5-alkylpyrazoles by a highly regioselective N-arylation of 3,5-disubstituted pyrazoles with 4-fluoronitrobenzene

被引：34

作者：

Wang, XJ

Tan, J

Grozinger, K

Betageri, R

Kirrane, T

Proudfoot, JR

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA

[2] Boehringer Ingelheim Pharmaceut Inc, Dept Med Chem, Ridgefield, CT 06877 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)00849-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Aryl-5-alkylpyrazoles undergo a highly regioselective arylation on N-1 atom with 4-fluoronitrobenzene in the presence of base to yield the corresponding 1-(4-nitrophenyl)pyrazoles. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5321 / 5324

页数：4

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