Detection and characterization of Enterobacteriaceae producing metallo-β-lactamases in a tertiary-care hospital in Spain

被引：38

作者：

Cendejas, E.

Gomez-Gil, R.

Gomez-Sanchez, P.

Mingorance, J. ^{[1
]}

机构：

[1] Hosp Univ La Paz, Microbiol Serv, Madrid 28046, Spain

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 02期

关键词：

Carbapenem resistance; Enterobacteriaceae; Escherichia coli; integron; Klebsiella pneumoniae; metallo-beta-lactamase; VIM-1; DOUBLE-DISK SYNERGY; KLEBSIELLA-PNEUMONIAE; INFECTIONS; PLASMID; TESTS;

D O I：

10.1111/j.1469-0691.2009.02888.x

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Carbapenem-resistant or intermediate (MIC >= 1 mg/L) clinical isolates (n = 12) of three species of Enterobacteriaceae (Klebsiella pneumoniae, Klebsiella oxytoca and Escherichia coli) were characterized. The isolates harboured integrons containing the VIM-1 metallo-beta-lactamase gene together with other resistance gene cassettes. In particular, the CTX-M-2 gene was detected in four of the K. pneumoniae isolates. The patient population was mostly paediatric and characterized by severe underlying illnesses that involved long-term hospitalization, major surgery and/or immunosuppressive and broad-spectrum antibiotic therapy.

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收藏

页码：181 / 183

页数：3

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