The complete genomic sequence of Nocardia farcinica IFM 10152

被引：224

作者：

Ishikawa, J ^{[1
]}

Yamashita, A

Mikami, Y

Hoshino, Y

Kurita, H

Hotta, K

Shiba, T

Hattori, M

机构：

[1] Natl Inst Infect Dis, Dept Bioact Mol, Tokyo 1628640, Japan

[2] Kitasato Univ, Inst Life Sci, Lab Genomic Informat, Sagamihara, Kanagawa 2288555, Japan

[3] Kitasato Univ, Sch Sci, Sagamihara, Kanagawa 2288555, Japan

[4] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Dept Mol Funct, Chiba 2608673, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 41期

关键词：

D O I：

10.1073/pnas.0406410101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.

引用

页码：14925 / 14930

页数：6

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