Colonoscopy-controlled intra-individual comparisons to screen relevant neoplasia: faecal immunochemical test vs. guaiac-based faecal occult blood test

被引：55

作者：

Oort, F. A. ^{[1
]}

Droste, J. S. Terhaar Sive ^{[1
]}

van der Hulst, R. W. M. ^{[2
]}

van Heukelem, H. A. ^{[3
]}

Loffeld, R. J. L. F. ^{[4
]}

Wesdorp, I. C. E. ^{[5
]}

van Wanrooij, R. L. J. ^{[1
]}

de Baaij, L. ^{[1
]}

Mutsaers, E. R. ^{[1
]}

van der Reijt, S. ^{[1
]}

Coupe, V. M. H. ^{[6
]}

Berkhof, J. ^{[6
]}

Bouman, A. A. ^{[7
]}

Meijer, G. A. ^{[8
]}

Mulder, C. J. J. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Gastroenterol & Hepatol, NL-1007 MB Amsterdam, Netherlands

[2] Kennemer Gasthuis, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

[3] Slotervaart Hosp, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

[4] Zaans Med Ctr, Dept Internal Med, Zaandam, Netherlands

[5] Sint Lucas Andreas Hosp, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands

[7] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1007 MB Amsterdam, Netherlands

[8] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, NL-1007 MB Amsterdam, Netherlands

来源：

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 2010年 / 31卷 / 03期

关键词：

AVERAGE-RISK POPULATION; COLORECTAL-CANCER; TASK-FORCE; SURVEILLANCE; GUIDELINES; PROGRAM; UPDATE;

D O I：

10.1111/j.1365-2036.2009.04184.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

P>Background Guaiac-based faecal occult blood tests (g-FOBTs) are most commonly used in colorectal cancer (CRC) screening programmes. Faecal immunochemical tests (FITs) are thought to be superior. Aim To compare performance of a g-FOBT and a quantitative FIT for detection of CRCs and advanced adenomas in a colonoscopy-controlled population. Methods We assessed sensitivity and specificity of both FIT (OC-sensor) and g-FOBT (Hemoccult-II) prior to patients' scheduled colonoscopies. Results Of the 62 invasive cancers detected in 1821 individuals, g-FOBT was positive in 46 and FIT in 54 (74.2% vs. 87.1%, P = 0.02). Among 194 patients with advanced adenomas, g-FOBT was positive in 35 and FIT in 69 (18.0% vs. 35.6%, P < 0.001). Sensitivity for screen relevant tumours (197 advanced adenomas and 28 stage I or II cancers) was 23.0% for g-FOBT and 40.5% for FIT (P < 0.001). Specificity of g-FOBT compared to FIT for the detection of cancer was 95.7% vs. 91.0%, P < 0.001) and for advanced adenomas (97.4% vs. 94.2%, P < 0.001). Conclusions Faecal immunochemical test is more sensitive for CRC and advanced adenomas. Sensitivity of FIT for screen relevant tumours, early-stage cancers and advanced adenomas, is significantly higher. Specificity of g-FOBT is higher compared with FIT.

引用

页码：432 / 439

页数：8

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