Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

被引：139

作者：

Weinstein, M ^{[1
]}

Yang, X ^{[1
]}

Deng, CX ^{[1
]}

机构：

[1] NIDDKD, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2000年 / 11卷 / 1-2期

关键词：

Smads; embryo; angiogenesis; immunity; cancer;

D O I：

10.1016/S1359-6101(99)00028-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Smad genes are the intracellular mediators of TGF-beta signals. Targeted mutagenesis in mice has yielded valuable new insights into the functions of this important gene family. These experiments have shown that Smad2 and Smad4 are needed for gastrulation, Smad5 for angiogenesis, and Smad3 for establishment of the mucosal immune response and proper development of the skeleton. In addition, these experiments have shown us the importance of gene dosage in this family, as several of its members yielded haploinsufficiency phenotypes, These include gastrulation and craniofacial defects for Smad2, accelerated wound healing for Smad3, and the incidence of gastric cancer for Smad4. Combinatorial genetics has also revealed functions of Smads in left/right isomerism and liver development. Published by Elsevier Science Ltd.

引用

页码：49 / 58

页数：10

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