Spasmolytic and anti-inflammatory effects of constituents from Hertia cheirifolia

被引：30

作者：

Ammar, Samia ^{[1
]}

Edziri, Hayet ^{[3
]}

Mahjoub, Mohamed Ali ^{[1
]}

Chatter, Rym ^{[2
]}

Bouraoui, Abderrahman ^{[2
]}

Mighri, Zine ^{[1
]}

机构：

[1] Fac Sci Monastir, Lab Chim Subst Nat & Synth Organ, UR 99, UR 12 26, Monastir 5000, Tunisia

[2] Fac Pharm, Unite Pharmacol Marine, Monastir 5000, Tunisia

[3] Fac Pharm, Lab Subst Biologiquement Acuves & Malad Transmiss, Monastir 5000, Tunisia

来源：

PHYTOMEDICINE | 2009年 / 16卷 / 12期

关键词：

Bakkenolide; Steroid compounds; Hertia cheirifolia; NMR; Spasmolytic activity; Anti-inflammatory activity; EREMOPHILENOLIDES; PLANTS; AURES;

D O I：

10.1016/j.phymed.2009.03.012

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A sesquiterpenoid Bakkenolide (1), and two steroids, (3 beta, 22E)-Stigmasta-5, 22-diene-3-ol (Stigmasterol) (2) and stigmasterol 3 beta-glucoside (3), isolated from the Hertia cheirifolia (L.) chloroform extract, were evaluated respectively for their spasmolytic and anti-inflammatory activities. We note that these natural products were isolated and purified for the first time from the specie Hertia cheirifolia Their structures have been established by spectroscopy (1 and 2D NMR experiences) and mass spectrometry. Chloroform-, ethyl acetate- and methanol-extracts were also tested for their spasmolytic and anti-inflammatory activities. Spasmolytic and anti-inflammatory screening were based respectively on the contractile response effects on rat isolated smooth muscles and on the dose-related carrageenan induced paw edema in rats. screening of the crude extracts showed spasmolytic and anti-inflammatory positive results. The antispasmodic effect of Bakkenolide was found in the same range as that of Alverine, a standard musculotropic spasmolytic agent. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：1156 / 1161

页数：6

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