White Matter and Information Processing Speed Following Treatment With Cranial-Spinal Radiation for Pediatric Brain Tumor

被引：46

作者：

Scantlebury, Nadia ^{[1
]}

Bouffet, Eric ^{[2
,3
]}

Laughlin, Suzanne ^{[4
,5
]}

Strother, Douglas ^{[6
,7
]}

McConnell, Dina ^{[8
]}

Hukin, Juliette ^{[9
,10
]}

Fryer, Christopher ^{[10
,11
]}

Laperriere, Normand ^{[12
,13
]}

Montour-Proulx, Isabelle ^{[14
]}

Keene, Daniel ^{[15
,16
]}

Fleming, Adam ^{[17
]}

Jabado, Nada ^{[17
]}

Liu, Fang ^{[1
]}

Riggs, Lily ^{[1
]}

Law, Nicole ^{[1
]}

Mabbott, Donald J. ^{[1
,18
]}

机构：

[1] Hosp Sick Children, Program Neurosci & Mental Hlth, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Dept Hematol Oncol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Dept Pediat, Toronto, ON M5S 1A1, Canada

[4] Hosp Sick Children, Diagnost Imaging, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[5] Univ Toronto, Dept Med Imaging, Toronto, ON M5S 1A1, Canada

[6] Univ Calgary, Dept Oncol, Calgary, AB T2N 1N4, Canada

[7] Univ Calgary, Dept Pediat, Calgary, AB T2N 1N4, Canada

[8] British Columbia Childrens Hosp, Dept Psychol, Vancouver, BC V6H 3V4, Canada

[9] Univ British Columbia, Dept Pediat, Div Neurol & Oncol, Vancouver, BC V6T 1W5, Canada

[10] British Columbia Childrens Hosp, Oncol Hematol Program, Vancouver, BC V6H 3V4, Canada

[11] Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1W5, Canada

[12] Princess Margaret Hosp, Ontario Canc Inst, Toronto, ON M4X 1K9, Canada

[13] Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[14] Childrens Hosp Eastern Ontario, Div Ambulatory Care Oncol, Ottawa, ON K1H 8L1, Canada

[15] Childrens Hosp Eastern Ontario, Ottawa, ON K1H 8L1, Canada

[16] Univ Ottawa, Fac Med, Dept Pediat, Ottawa, ON K1N 6N5, Canada

[17] Montreal Childrens Hosp, Paediat Oncol, Quebec City, PQ, Canada

[18] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada

来源：

NEUROPSYCHOLOGY | 2016年 / 30卷 / 04期

关键词：

white matter tracts; information processing speed; pediatric brain tumors; diffusion tensor imaging; cranial-spinal radiation; CHOICE-REACTION TIME; LONG-TERM SURVIVORS; CRANIOSPINAL IRRADIATION; ADJUVANT CHEMOTHERAPY; NERVOUS-SYSTEM; CHILDREN; DIFFUSION; CHILDHOOD; MEMORY; THERAPY;

D O I：

10.1037/neu0000258

中图分类号：

B849 [应用心理学];

学科分类号：

040203 [应用心理学];

摘要：

Objective: We compared the structure of specific white matter tracts and information processing speed between children treated for posterior fossa tumors with cranial-spinal radiation (n = 30), or with surgery +/- focal radiation (n = 29), and healthy children (n = 37). Method: Probabilistic diffusion tensor imaging (DTI) tractography was used to delineate the inferior longitudinal fasciculi, optic radiation, inferior frontal occipital fasciculi, and uncinate fasciculi bilaterally. Information processing speed was measured using the coding and symbol search subtests of the Wechsler Intelligence Scales, and visual matching, pair cancellation, and rapid picture naming subtests of the Woodcock-Johnson Test of Cognitive Ability, 3rd revision. We examined group differences using repeated measures MANOVAs and path analyses were used to test the relations between treatment, white matter structure of the tracts, and information processing speed. Results: DTI indices of the optic radiations, the inferior longitudinal fasciculi, and the inferior fronto-occipital fasciculi differed between children treated with cranial-spinal radiation and children treated with surgery +/- focal radiation, and healthy controls (p = .045). Children treated with cranial-spinal radiation also exhibited lower processing speed scores relative to healthy control subjects (p = .002). Notably, we observed that group differences in information processing speed were related to the structure of the right optic radiation (p = .002). Conclusion: We show that cranial-spinal radiation may have a negative impact on information processing speed via insult to the right optic radiations.

引用

页码：425 / 438

页数：14

共 67 条

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