Development and function of B-1 cells - Commentary

被引：173

作者：

Hayakawa, K ^{[1
]}

Hardy, RR ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Inst Canc Res, Philadelphia, PA 19111 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00098-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Results from immunoglobulin-transgenic mice and BCR-mutant mice have been widely interpreted in recent years as supporting a simple 'activation' model for the origin of CD5+/B-1 B cells. However cell transfer experiments over 10 years ago and recent work investigating pre-BCR signaling suggest striking differences between B cell development in fetal liver and adult bone marrow, lending support for a 'lineage' model that we favor. Recent progress has been made relating to the development and function of the CD5+/B-1 B cell subpopulation in mice; the data can be viewed in the context of the generation of this subpopulation by a distinctive fetal B cell developmental process.

引用

页码：346 / 353

页数：8

共 62 条

[51]

Sen G, 1999, EUR J IMMUNOL, V29, P3319

[52]

Simarro M, 1999, J IMMUNOL, V162, P5149

[53] Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase [J].

Suzuki, H ;

Terauchi, Y ;

Fujiwara, M ;

Aizawa, S ;

Yazaki, Y ;

Kadowaki, T ;

Koyasu, S .

SCIENCE, 1999, 283 (5400) :390-392

[54] Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene [J].

Takeshita, H ;

Taniuchi, R ;

Kato, J ;

Watanabe, T .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (04) :435-444

[55] Early induction of cyclin D2 expression in phorbol ester-responsive B-1 lymphocytes [J].

Tanguay, DA ;

Colarusso, TP ;

Pavlovic, S ;

Irigoyen, M ;

Howard, RG ;

Bartek, J ;

Chiles, TC ;

Rothstein, TL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) :1685-1690

[56] Selection at multiple checkpoints focuses VH12B cell differentiation toward a single B-1 cell specificity [J].

Tatu, C ;

Ye, J ;

Arnold, LW ;

Clarke, SH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) :903-914

[57]

tenBoekel E, 1997, IMMUNITY, V7, P357

[58] Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population [J].

Vink, A ;

Warnier, G ;

Brombacher, F ;

Renauld, JC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (09) :1413-1423

[59] A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly [J].

Wasserman, R ;

Li, YS ;

Shinton, SA ;

Carmack, CE ;

Manser, T ;

Wiest, DL ;

Hayakawa, K ;

Hardy, RR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (02) :259-264

[60] Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment [J].

Watanabe, N ;

Nisitani, S ;

Ikuta, K ;

Suzuki, M ;

Chiba, T ;

Honjo, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (04) :461-469

← 1 2 3 4 5 6 7 →