Coagulation problems in liver disease

被引：50

作者：

Rapaport, SI ^{[1
]}

机构：

[1] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2000年 / 11卷

关键词：

cirrhosis; recombinant activated factor VIIa (rFVIIa); thrombin generation; fibrinolysis;

D O I：

10.1097/00001721-200004001-00014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three topics are addressed in this manuscript: (1) the causes of abnormal hemostasis in cirrhosis; (2) the evaluation of hemostasis in cirrhotic patients before invasive procedures or in the presence of bleeding; and (3) the assessment of the effect of recombinant activated factor VII (rFVIIa; NovoSeven(R), Novo Nordisk A/S, Bagsvaerd, Denmark) on hemostatic function in cirrhotic patients. Laboratory experiments are described that could enhance the understanding of the effect of rFVIIa on blood coagulation during hemostasis in cirrhotic patients. Blood Coagul Fibrinolysis 11 (suppl 1):S69-S74 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：S69 / S74

页数：6

共 29 条

[1] TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex [J].