Alasmontamine A, A First Tetrakis Monoterpene Indole Alkaloid from Tabernaemontana elegans

被引：46

作者：

Hirasawa, Yusuke ^{[1
]}

Miyama, Saori ^{[1
]}

Hosoya, Takahiro ^{[1
]}

Koyama, Koichiro ^{[1
]}

Rahman, Abdul ^{[2
]}

Kusumawati, Idha ^{[2
]}

Zaini, Noor Cholies ^{[2
]}

Morita, Hiroshi ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Airlangga Univ, Fac Pharm, Surabaya 60286, Indonesia

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 24期

关键词：

NATURALLY OCCURRING SUBSTANCES; BISINDOLE ALKALOIDS; SPECTROSCOPY; VOACANGA;

D O I：

10.1021/ol902420s

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A novel tetrakis monoterpene indole alkaloid, alasmontamine A (1) consisting of bis-vobtusine-type skeletons, was isolated from the leaves of Tabernaemontana elegans. The structure including the relative stereochemistry was elucidated on the basis of spectroscopic data. Alasmontamine A (1) exhibited moderate cell growth inhibitory activity against HL-60 cells.

引用

页码：5718 / 5721

页数：4

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