Chylomicronemia Elicits Atherosclerosis in Mice-Brief Report

被引：96

作者：

Weinstein, Michael M. ^{[1
,2
]}

Yin, Liya ^{[1
]}

Tu, Yiping ^{[1
]}

Wang, Xuping ^{[1
]}

Wu, Xiaohui ^{[1
]}

Castellani, Lawrence W. ^{[1
]}

Walzem, Rosemary L. ^{[3
]}

Lusis, Aldons J. ^{[1
,2
]}

Fong, Loren G. ^{[1
]}

Beigneux, Anne P. ^{[1
]}

Young, Stephen G. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90024 USA

[3] Texas A&M Univ, Dept Poultry Sci, College Stn, TX 77843 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2010年 / 30卷 / 01期

关键词：

lipoprotein lipase; chylomicronemia; lipolysis; GPIHBP1; LIPASE-DEFICIENT MICE; LIPOPROTEIN-LIPASE; APOLIPOPROTEIN B48; B100;

D O I：

10.1161/ATVBAHA.109.196329

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective-The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis. Methods and Results-Gpihbp1(-/-) mice on a chow diet have plasma triglyceride and cholesterol levels of 2812 +/- 209 and 319 +/- 27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient "apo-B48-only" mice and Gpihbp1-deficient "apo-B100-only" mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48-and apo-B100-containing lipoproteins. Conclusions-Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48- and apo-B100-containing lipoproteins. (Arterioscler Thromb Vasc Biol. 2010;30:20-23.)

引用

页码：20 / 23

页数：4

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