Increased plasma concentrations of interleukin-18 in acute coronary syndromes

被引：127

作者：

Mallat, Z ^{[1
]}

Henry, P ^{[1
]}

Fressonnet, R ^{[1
]}

Alouani, S ^{[1
]}

Scoazec, A ^{[1
]}

Beaufils, P ^{[1
]}

Chvatchko, Y ^{[1
]}

Tedgui, A ^{[1
]}

机构：

[1] Hop Lariboisiere, INSERM, U541, F-75475 Paris 10, France

来源：

HEART | 2002年 / 88卷 / 05期

关键词：

D O I：

10.1136/heart.88.5.467

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To examine the relation between plasma concentrations of interleukin-18 (IL-18), the interferon gamma inducing factor, and clinical instability of coronary artery disease. Design and setting: Observational study in a university hospital. Patients: 11 patients with unstable angina and negative troponin 1, 2 1 patients with acute non-Q wave myocardial infarction (MI), 21 patients with acute Q wave MI, 9 patients with stable angina, and 11 controls. Main outcome measures: Plasma IL-18 concentrations and their relation to clinical instability and myocardial dysfunction. Results: Plasma concentrations of IL-18 were significantly increased in the unstable angina and MI groups in comparison with the stable angina and control groups (p < 0.01). No difference in IL-18 concentrations were found between patients with unstable angina, patients with non-Q wave MI, and patients with Q wave MI. Plasma IL-18 concentrations significantly correlated with decreased left ventricular ejection fraction (p = 0.01). Conclusions: Plasma IL-18 concentrations are increased in patients with acute coronary syndromes and correlate with the severity of myocardial dysfunction.

引用

页码：467 / 469

页数：3

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