Association of Plasma Vitamin D Levels with Adiposity in Hispanic and African Americans

被引:142
作者
Young, Kendra A. [1 ]
Engelman, Corinne D. [2 ]
Langefeld, Carl D. [3 ]
Hairston, Kristen G. [3 ]
Haffner, Steven M. [4 ]
Bryer-Ash, Michael [5 ]
Norris, Jill M. [1 ]
机构
[1] Univ Colorado Denver, Colorado Sch Publ Hlth, Aurora, CO 80045 USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI 53706 USA
[3] Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27157 USA
[4] Univ Texas Hlth Sci Ctr San Antonio, Div Clin Epidemiol, San Antonio, TX 78229 USA
[5] Univ Oklahoma, Hlth Sci Ctr, Harold Hamm Diabet Ctr, Oklahoma City, OK 73104 USA
基金
美国国家卫生研究院;
关键词
METABOLIC SYNDROME; HYPOVITAMINOSIS-D; INSULIN SENSITIVITY; OBESE CHILDREN; WEIGHT-GAIN; OLDER MEN; BODY-FAT; PREVALENCE; ADULTS; 25-HYDROXYVITAMIN-D;
D O I
10.1210/jc.2009-0079
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: Previous studies have suggested vitamin D insufficiency is associated with increased obesity; however, the relationship between 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH](2)D) and measures of adiposity has not been well characterized in minority populations. Objective: The objective of the study was to examine the relationship between levels of 25[OH]D and 1,25[OH](2)D and measures of adiposity in Hispanic and African-Americans at baseline and on change in these measures over time. Design and Setting: The Insulin Resistance Atherosclerosis (IRAS) Family Study examined 917 Hispanics and 439 African-Americans at baseline and again 5.3 yr later (n = 1081 at follow-up). Main Outcome Measure: 25[OH]D(nanograms per milliliter) and 1,25[OH](2)D(picograms per milliliter) were measured at baseline. Abdominal sc adipose tissue (SAT), visceral adipose tissue (VAT; both determined by computed tomography scan), and body mass index (BMI) were measured at baseline and follow-up. Results: 25[OH]D was inversely associated with BMI, VAT, and SAT in both populations at baseline (P < 0.001). 25[OH]D was marginally inversely associated with baseline visceral fat to sc fat ratio in African-Americans (P = 0.049) but not Hispanics. 1,25[OH](2)D was inversely associated with BMI (P < 0.0001, P = 0.002) and VAT (P = 0.0005, P = 0.012) in Hispanics and African-Americans, respectively, whereas 1,25[OH](2)D was inversely associated with SAT in Hispanics(P < 0.0001) and with visceral fattosc fat ratio in African-Americans (P = 0.02). Adjusting for 25[OH]D attenuated these associations; 1,25[OH](2)D remained associated with BMI in both populations (P < 0.05) and with SAT (P = 0.004) in Hispanics. No significant associations between 5-yr change in adiposity and 25[OH]D or 1,25[OH](2)D were seen. Conclusions: Vitamin D levels were inversely associated with baseline BMI, SAT, and VAT in Hispanic and African-Americans but were not associated with 5-yr change in adiposity. (J Clin Endocrinol Metab 94: 3306-3313, 2009)
引用
收藏
页码:3306 / 3313
页数:8
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