Measurement of high resolution ECG QT interval during controlled euglycaemia and hypoglycaemia

被引:27
作者
Ireland, RH [1 ]
Robinson, RTCE
Heller, SR
Marques, JLB
Harris, ND
机构
[1] Univ Sheffield, Royal Hallamshire Hosp, Dept Med Phys & Clin Engn, Sheffield S10 2JF, S Yorkshire, England
[2] No Gen Hosp, Ctr Diabet, Sheffield S5 7AU, S Yorkshire, England
[3] Univ Fed Santa Catarina, Dept Engn Elet, BR-88040900 Florianopolis, SC, Brazil
关键词
high resolution EGG; QT interval measurement; hypoglycaemia; T wave maximal amplitude; diabetes;
D O I
10.1088/0967-3334/21/2/309
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
During hypoglycaemia, typically there is a change in the surface ECG characterized by a flattened and prolonged T wave, often accompanied by a fused U wave. The QT interval is a useful parameter for quantifying the ECG morphology. However, reliable measurement of QT is not straightforward, particularly for hypoglycaemic ECG morphology. The objective of this study was to compare the ability of two methods of QT measurement to distinguish between ECGs recorded during euglycaemia and hypoglycaemia. The first method involves manually setting the intersection of the isoelectric line and the T wave or, where this is not possible, the nadir between the T and U wave. The second method is semi-automatic and fits a tangent to the point of maximum gradient on the downward slope of the T wave. Two independent observers used both methods to measure the QT for high resolution ECG data recorded during a study of 17 non-diabetic subjects undergoing controlled euglycaemia and hypoglycaemia. Using the mean results of the two observers, the mean +/- SD increase in heart rate corrected QT, QTc, for ECGs recorded during euglycaemia and hypoglycaemia was 32 +/- 25 ms for the non-tangent method and 60 +/- 24 ms for the tangent method. Therefore, the tangent method provides greater distinction between ECGs recorded during euglycaemia and hypoglycaemia than the non-tangent method. A potential clinical application could be the non-invasive detection of impending hypoglycaemia at night, which would be of significant benefit to adults and young children with diabetes.
引用
收藏
页码:295 / 303
页数:9
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