Sequestosome 1/p62 - More than just a scaffold

被引：133

作者：

Seibenhener, M. Lamar ^{[1
]}

Geetha, Thangiah ^{[1
]}

Wooten, Marie W. ^{[1
]}

机构：

[1] Auburn Univ, Program Cellular & Mol Biosci, Dept Sci Biol, Auburn, AL 36849 USA

来源：

FEBS LETTERS | 2007年 / 581卷 / 02期

关键词：

polyubiquitin; p62; scaffold; atypical protein kinase C;

D O I：

10.1016/j.febslet.2006.12.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor internalization, and protein turnover. Herein we review recent advances in the field. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：175 / 179

页数：5

共 31 条

[1] Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation [J].

Babu, JR ;

Geetha, T ;

Wooten, MW .

JOURNAL OF NEUROCHEMISTRY, 2005, 94 (01) :192-203

[2] Rad23 promotes the targeting of proteolytic substrates to the proteasome [J].

Chen, L ;

Madura, K .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (13) :4902-4913

[3] ZIP3, a new splice variant of the PKC-ζ-interacting protein family, binds to GABAc receptors, PKC-ζ, and Kvβ2 [J].

Croci, C ;

Brandstätter, JH ;

Enz, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (08) :6128-6135

[4] Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr [J].

Dieckmann, T ;

Withers-Ward, ES ;

Jarosinski, MA ;

Liu, CF ;

Chen, ISY ;

Feigon, J .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (12) :1042-1047

[5] Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling [J].

Geetha, T ;

Jiang, JX ;

Wooten, MW .

MOLECULAR CELL, 2005, 20 (02) :301-312

[6] Structure and functional properties of the ubiquitin binding protein p62 [J].

Geetha, T ;

Wooten, MW .

FEBS LETTERS, 2002, 512 (1-3) :19-24

[7] Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2 [J].

Gong, JP ;

Xu, J ;

Bezanilla, M ;

van Huizen, R ;

Derin, R ;

Li, M .

SCIENCE, 1999, 285 (5433) :1565-1569

[8] The UBA2 domain functions as an intrinsic stabilization signal that protects Rad23 from proteasomal degradation [J].

Heessen, S ;

Masucci, MG ;

Dantuma, NP .

MOLECULAR CELL, 2005, 18 (02) :225-235

[9] Solution structure of atypical protein kinase CPB1 domain and its mode of interaction with ZIP/p62 and MEK5 [J].

Hirano, Y ;

Yoshinaga, S ;

Ogura, K ;

Yokochi, M ;

Noda, Y ;

Sumimoto, H ;

Inagaki, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (30) :31883-31890

[10] Regulation of ubiquitin-binding proteins by monoubiquitination [J].

Hoeller, D ;

Crosetto, N ;

Blagoev, B ;

Raiborg, C ;

Tikkanen, R ;

Wagner, S ;

Kowanetz, K ;

Breitling, R ;

Mann, M ;

Stenmark, H ;

Dikic, I .

NATURE CELL BIOLOGY, 2006, 8 (02) :163-U45

← 1 2 3 4 →