Pandemic (H1N1) 2009 virus outbreak in a school in London, April-May 2009: an observational study

被引：52

作者：

Calatayud, L. ^{[2
,3
]}

Kurkela, S. ^{[3
,4
]}

Neave, P. E. ^{[5
]}

Brock, A. ^{[5
]}

Perkins, S. ^{[5
]}

Zuckerman, M. ^{[6
]}

Sudhanva, M. ^{[6
]}

Bermingham, A. ^{[3
]}

Ellis, J. ^{[3
]}

Pebody, R. ^{[3
]}

Catchpole, M. ^{[3
]}

Heathcock, R. ^{[5
]}

Maguire, H. ^{[1
]}

机构：

[1] Hlth Protect Agcy, Reg Epidemiol Unit, London WC1V 7PP, England

[2] European Ctr Dis Control, EPIET, Stockholm, Sweden

[3] Hlth Protect Agcy, Ctr Infect, London WC1V 7PP, England

[4] European Ctr Dis Control, European Publ Hlth Microbiol Training Programme E, Stockholm, Sweden

[5] SE London Hlth Protect Unit, London, England

[6] Kings Coll Hosp NHS Fdn Trust, London Reg Lab, Hlth Protect Agcy, London, England

来源：

EPIDEMIOLOGY AND INFECTION | 2010年 / 138卷 / 02期

关键词：

Infection control; infection transmission; outbreaks; respiratory infections; swine-origin influenza A H1N1 virus; SWINE FLU OUTBREAK; INFLUENZA; TRANSMISSION; INFECTIONS;

D O I：

10.1017/S0950268809991191

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

On 29 April 2009, an imported case of pandemic (H1N1) 2009 virus infection was detected in a London school. As further cases, pupils and staff members were identified, school closure and mass prophylaxis were implemented. An observational descriptive study was conducted to provide an insight into the clinical presentation and transmission dynamics in this setting. Between 15 April and 15 May 2009, 91 symptomatic cases were identified: 33 were confirmed positive for pandemic (H1N1) 2009 virus infection; 57 were tested negative; in one the results were unavailable. Transmission occurred first within the school, and subsequently outside. Attack rates were 2% in pupils (15% in the 11-12 years age group) and 17% in household contacts. The predominant symptoms were fever (97%), respiratory symptoms (91%), and sore throat (79%). Limited spread in the school may have been due to a combination of school closure and mass prophylaxis. However, transmission continued through household contacts to other schools.

引用

页码：183 / 191

页数：9

共 17 条

[1] Transmission of influenza A in human beings [J].

Brankston, Gabrielle ;

Gitterman, Leah ;

Hirji, Zahir ;

Lemieux, Camille ;

Gardam, Michael .

LANCET INFECTIOUS DISEASES, 2007, 7 (04) :257-265

[2] UN warns that swine flu outbreak could turn into pandemic [J].

Charatan, Fred .

BRITISH MEDICAL JOURNAL, 2009, 338

[3] SWINE FLU OUTBREAK Out of Mexico? Scientists Ponder Swine Flu's Origins [J].

Cohen, Jon .

SCIENCE, 2009, 324 (5928) :700-702

[4] Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team [J].

Dawood, Fatimah S. ;

Jain, Seema ;

Finelli, Lyn ;

Shaw, Michael W. ;

Lindstrom, Stephen ;

Garten, Rebecca J. ;

Gubareva, Larisa V. ;

Xu, Xiyan ;

Bridges, Carolyn B. ;

Uyeki, Timothy M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (25) :2605-2615

[5] Social contact networks for the spread of pandemic influenza in children and teenagers [J].

Glass, Laura M. ;

Glass, Robert J. .

BMC PUBLIC HEALTH, 2008, 8 (1)

[6] Targeted social distancing design for pandemic influenza [J].

Glass, Robert J. ;

Glass, Laura M. ;

Beyeler, Walter E. ;

Min, H. Jason .

EMERGING INFECTIOUS DISEASES, 2006, 12 (11) :1671-1681

[7] Herd protection against influenza [J].

Glezen, W. Paul .

JOURNAL OF CLINICAL VIROLOGY, 2006, 37 (04) :237-243

[8] Influenza virus infections in infants [J].

Glezen, WP ;

Taber, LH ;

Frank, AL ;

Gruber, WC ;

Piedra, PA .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1997, 16 (11) :1065-1068

[9]

Hlth Protection Agcy, 2009, EUROSURVEILLANCE, V14

[10]

Jordan H. T., 2009, Morbidity and Mortality Weekly Report, V58, P470

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