Recent Advances in the Identification of γ-Secretase Inhibitors To Clinically Test the Aβ Oligomer Hypothesis of Alzheimer's Disease

被引：85

作者：

Kreft, Anthony F. ^{[1
]}

Martone, Robert ^{[1
]}

Porte, Alexander ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Princeton, NJ 08543 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 52卷 / 20期

关键词：

AMYLOID PRECURSOR PROTEIN; INTRAMEMBRANE-CLEAVING PROTEASES; APPENDED N-ALKYLSULFONAMIDES; IMPAIR SYNAPTIC PLASTICITY; C-TERMINAL FRAGMENT; CEREBROSPINAL-FLUID; PEPTIDOMIMETIC INHIBITORS; ARYLSULFONYL PIPERIDINES; ASYMMETRIC-SYNTHESIS; THERAPEUTIC TARGETS;

D O I：

10.1021/jm900188z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：6169 / 6188

页数：20

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