Inheritance of pancreatic cancer in pancreatic cancer-prone families

被引：19

作者：

Banke, MG

Mulvihill, JJ

Aston, CE

机构：

[1] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15261 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Childrens Hosp Oklahoma, Dept Genet, Oklahoma City, OK USA

[3] Univ Oklahoma, Hlth Sci Ctr, Childrens Hosp Oklahoma, Dept Pediat, Oklahoma City, OK USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2000年 / 84卷 / 03期

关键词：

D O I：

10.1016/S0025-7125(05)70250-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Families are being increasingly recognized as carrying an inherited susceptibility for pancreatic cancer, apparently unrelated to any currently recognized syndrome. The authors provide a review of the current evidence for familial susceptibility to pancreatic cancer. A formal segregation analysis of the pattern of inheritance of pancreatic cancer in 70 families from the National Registry for Familial Pancreatic Cancer is described. This analysis suggests a single major gene with an autosomal dominant mode of inheritance controlling susceptibility for pancreatic cancer in these families.

引用

页码：677 / +

页数：16

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