Urinary catecholamines and cortisol in recent-onset posttraumatic stress disorder after motor vehicle accidents

被引:100
作者
Hawk, LW
Dougall, AL
Ursano, RJ
Baum, A
机构
[1] Univ Pittsburgh, Pittsburgh, PA 15260 USA
[2] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA
来源
PSYCHOSOMATIC MEDICINE | 2000年 / 62卷 / 03期
关键词
posttraumatic stress disorder; cortisol; catecholamines; psychoendocrine; gender differences;
D O I
10.1097/00006842-200005000-00016
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: This study examined relationships among stress hormone levels, posttraumatic stress disorder (PTSD) diagnosis and symptoms, and gender shortly after a common civilian trauma. Methods: Levels of catecholamines and cortisol in 15-hour urine samples were examined in 55 adults who had been in serious motor vehicle accidents and in 22 age-matched control. Results: Catecholamines were related to PTSD diagnosis and symptoms, but only among men: PTSD-symptomatic men who had been in an accident exhibited elevated levels of epinephrine and norepinephrine 1 month after the accident and had higher epinephrine levels 5 months later. intrusive thoughts predicted catecholamine levels at 1 month, and avoidance of trauma-relevant stimuli was associated with higher epinephrine levels 5 months later. These effects were not significant among women. Urinary cortisol was also elevated among PTSD-symptomatic men, but not women, and only immediately (1 month) after the accident. For men and women, greater emotional numbing predicted a lower cortisol level 6 months after the accident. Conclusions: These findings were interpreted as limited support for the generalizability of findings in men with chronic, combat-related PTSD and indicate the need for additional research on psychoendocrine assessment of traumatized women and specific dimensions of PTSD symptomatology.
引用
收藏
页码:423 / 434
页数:12
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