Activities of taurolidine in vitro and in experimental enterococcal endocarditis

被引：69

作者：

Torres-Viera, C

Thauvin-Eliopoulos, C

Souli, M

DeGirolami, P

Farris, MG

Wennersten, CB

Sofia, RD

Eliopoulos, GM

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Wallace Labs, Cranbury, NJ 08512 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 06期

关键词：

D O I：

10.1128/AAC.44.6.1720-1724.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In vitro, the antimicrobial agent taurolidine inhibited virtually ail of the bacteria tested, including vanco-mycin-resistant enterococci, oxacillin-resistant staphylococci, and Stenotrophomonas maltophilia, at concentrations between 250 and 2,000 mu g/ml. Taurolidine was not effective in experimental endocarditis. While it appears unlikely. that this antimicrobial would be useful for systemic therapy, its bactericidal activity and the resistance rates found (<10(-9)) are favorable indicators for its possible development for topical use.

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页码：1720 / 1724

页数：5

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