Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?

被引：4

作者：

Collu, Giovanna M. ^{[1
]}

Meurette, Olivier ^{[1
]}

Brennan, Keith ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

BREAST CANCER RESEARCH | 2009年 / 11卷 / 04期

关键词：

CYCLIN D1 EXPRESSION; EPITHELIAL-CELLS; PATHWAY; TRANSACTIVATION; MECHANISM; MOTILITY; TUMORS;

D O I：

10.1186/bcr2336

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Increased Wnt signalling has been implicated in the aetiology of many different human cancers, including breast cancers. In most cases, Wnt signalling is thought to drive tumourigenesis through the stabilisation of cytosolic beta-catenin and the subsequent changes in the expression of T-cell factor (TCF)-dependent genes. However, this is not necessarily the only mechanism, as Wnt proteins can signal through a number of different intracellular signalling pathways. The ongoing work from Nancy Hynes' laboratory continues to highlight this latter possibility.

引用

页数：2

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