Natural history of GBV-C hepatitis G virus infection through the follow-up of GBV-C hepatitis G virus-infected blood donors and recipients studied by RNA polymerase chain reaction and anti-E2 serology

被引:47
作者
Lefrere, JJ
Loiseau, P
Maury, J
Lasserre, J
Mariotti, N
Ravera, N
Lerable, J
Lefevre, G
MorandJoubert, T
Girot, R
机构
[1] HP, AP, ETABLISSEMENT TRANSFUS SANGUINE, PARIS, FRANCE
[2] HOP TENON, BIOCHIM LAB, F-75970 PARIS, FRANCE
[3] HOP ST ANTOINE, VIROL LAB, F-75571 PARIS, FRANCE
[4] HOP TENON, HEMATOL LAB, F-75970 PARIS, FRANCE
关键词
D O I
10.1182/blood.V90.9.3776
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aims of this study were to determine the outcome and the natural history of GBV-C/hepatitis G virus (HGV) infection and to establish the frequency of acute or persistent infections in multiply-transfused individuals and blood donors, We used a GBV-C/HGV RNA polymerase chain reaction (PCR) and an assay evidencing antibodies to the envelop protein E2, which is considered a marker for virus clearance. Among 16 PCR-positive recipients, 11 were still positive for GBV-C/HGV RNA at the end of the study period; six of the 16 recipients were GBV-C/HGV infected during the study period and thus had a well-defined date of infection. The 16 patients were shown to carry GBV-C/HGV RNA over a mean period of 4.4 years, for a mean observational period (defined as the follow-up period since the first sample positive for GBV-C/MGV RNA) of 5.3 years, Within the limits of the study period, the patients with a well-defined date of infection were positive for GaV-C/HGV RNA during a mean period of 4.7 years, If defined by the presence of GBV-C/HGV RNA for at least 6 months, the persistent infection rate was 100% in this recipient cahort. Serum anti-E2 antibody was evidenced at least once in five (31.2%) recipients and, except in one case, became detectable after the loss of GBV-C/HGV RNA, among the 11 blood donors, all were still positive for GBV-C/HGV RNA after a mean follow-up period of 7.7 months, The persistent infection rate was 100% in this donor cohort, Once acquired, the infection to GBV-C/HGV generally tends to persist in immunocompetent patients. (C) 1997 by The American Society of Hematology.
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页码:3776 / 3780
页数:5
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