Molecular recognition of NADP(H) and ATP by macrocyclic polyamines bearing acridine groups

被引：70

作者：

Fenniri, H ^{[1
]}

Hosseini, MW ^{[1
]}

Lehn, JM ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,INST BEL,CNRS URA 422,LAB CHIM SUPRAMOL,F-67000 STRASBOURG,FRANCE

来源：

HELVETICA CHIMICA ACTA | 1997年 / 80卷 / 03期

关键词：

D O I：

10.1002/hlca.19970800314

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The macrocyclic polyamine-based receptor BA bearing two acridine units makes use of combined electrostatic and stacking interactions for the binding of nucleotide polyphosphates and for the recognition of ATP and of NADPH (k(a) > 3 . 10(8) M), with a high selectivity for NADPH vs. NADP (ca. 10(3)) and NAD(H) (> 10(6)). The binding properties of this receptor towards a variety of substrates led to its in vitro application as a fluorescent probe for ATP. BA also interacts strongly with nucleic acids as shown by spectrophotometric, spectrofluorimetic, and electrophoretic mobility methods.

引用

页码：786 / 803

页数：18

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