Therapeutic manipulation of immune tolerance in allergic disease

被引：176

作者：

Akdis, Muebeccel ^{[1
]}

Akdis, Cezmi A. ^{[1
]}

机构：

[1] Univ Zurich, Swiss Inst Allergy & Asthma Res, SIAF, CH-7270 Davos, Switzerland

来源：

NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 08期

关键词：

REGULATORY T-CELLS; NECROSIS-FACTOR-ALPHA; MODIFIED TH2 RESPONSE; BIRCH POLLEN ALLERGY; TOLL-LIKE RECEPTOR-4; SUBLINGUAL IMMUNOTHERAPY; DOUBLE-BLIND; FUSION PROTEIN; RHEUMATOID-ARTHRITIS; BEE VENOM;

D O I：

10.1038/nrd2653

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Immune tolerance-the adaptation of the immune system to external antigens or allergens-might be therapeutically manipulated to restore normal immunity in conditions such as allergy, asthma and autoimmune diseases. The field of allergen-specific immunotherapy is experiencing exciting and novel developments for the treatment of allergic and autoimmune diseases, and recent insights into the reciprocal regulation and counter-balance between different T-cell subsets is foreseen to facilitate new strategies for immunointervention. This Review highlights current knowledge of immunomodulatory therapies for the manipulation of immune tolerance and highlights recent approaches to improve allergen-specific immunotherapy for the treatment of allergic diseases.

引用

页码：645 / 660

页数：16

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