Natural PTP1B inhibitors from Broussonetia papyrifera

被引：104

作者：

Chen, RM ^{[1
]}

Hu, LH ^{[1
]}

An, TY ^{[1
]}

Li, J ^{[1
]}

Shen, Q ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Chinese Natl Ctr Drug Screening, Shanghai 200031, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(02)00757-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4'.7-trihdroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods. Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme, (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3387 / 3390

页数：4

共 15 条

[1] NUCLEAR MAGNETIC RESONANCE SPECTRA OF FLAVONOIDS [J].