Evidence for Epistasis Between SLC6A4 and a Chromosome 4 Gene as Risk Factors in Major Depression

被引：8

作者：

Neff, Chris D. ^{[2
]}

Abkevich, Victor ^{[2
]}

Potter, Jennifer ^{[2
]}

Riley, Robin ^{[2
]}

Shattuck, Donna ^{[2
]}

Katz, David A. ^{[1
]}

机构：

[1] Abbott Labs, Abbott Pk, IL 60064 USA

[2] Myriad Genet, Salt Lake City, UT USA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2010年 / 153B卷 / 01期

关键词：

genetic linkage; major depressive disorder; serotonin transporter; gene-gene interaction; complex disease genetics; BIPOLAR DISORDER; LOCI; LINKAGE; SCAN; ANXIETY; STRESS;

D O I：

10.1002/ajmg.b.30979

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression. (C) 2009 Wiley-Liss, Inc.

引用

收藏

页码：321 / 322

页数：2

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