Evidence for Epistasis Between SLC6A4 and a Chromosome 4 Gene as Risk Factors in Major Depression

被引:8
作者
Neff, Chris D. [2 ]
Abkevich, Victor [2 ]
Potter, Jennifer [2 ]
Riley, Robin [2 ]
Shattuck, Donna [2 ]
Katz, David A. [1 ]
机构
[1] Abbott Labs, Abbott Pk, IL 60064 USA
[2] Myriad Genet, Salt Lake City, UT USA
关键词
genetic linkage; major depressive disorder; serotonin transporter; gene-gene interaction; complex disease genetics; BIPOLAR DISORDER; LOCI; LINKAGE; SCAN; ANXIETY; STRESS;
D O I
10.1002/ajmg.b.30979
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学];
摘要
Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:321 / 322
页数:2
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