Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay

被引：37

作者：

Jeffrey, AM ^{[1
]}

Williams, GM ^{[1
]}

机构：

[1] New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2000年 / 38卷 / 04期

关键词：

DNA damage; genotoxic; hepatocytes; sweeteners; unscheduled DNA synthesis;

D O I：

10.1016/S0278-6915(99)00163-5

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The non-nutritive sweeteners acesulfame-K, aspartame, cyclamate, saccharin and sucralose were tested for DNA damaging activity in the rat hepatocyte/DNA repair assay. Using hepatocytes from F344 and Sprague-Dawley male rats, all were inactive despite strong responses for the positive control, 2-amino-fluorene, (C), 2000 Elsevier Science Lid. All rights reserved.

引用

页码：335 / 338

页数：4

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