The Unfolded Protein Response: At the intersection between endoplasmic Reticulum Function and Mitochondrial Bioenergetics

被引：46

作者：

Carreras-Sureda, Amado ^{[1
,2
,3
]}

Pihan, Philippe ^{[1
,2
,3
]}

Hetz, Claudio ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Chile, Fac Med, Ctr Gerosci Brain Hlth & Metab, Santiago, Chile

[2] Univ Chile, Fac Med, Biomed Neurosci Inst, Santiago, Chile

[3] Univ Chile, Inst Biomed Sci, Program Cellular & Mol Biol, Santiago, Chile

[4] Buck Inst Res Aging, Novato, CA USA

[5] Harvard Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA

来源：

FRONTIERS IN ONCOLOGY | 2017年 / 7卷

关键词：

mitochondria-associated membranes; unfolded protein response; endoplasmic reticulum stress; mitochondria; cancer; MITOFUSIN; 2; ER STRESS; CALCIUM HOMEOSTASIS; BAX INHIBITOR-1; CA2+ TRANSFER; CALNEXIN; CANCER; PROTEOSTASIS; MEMBRANES; PATHWAY;

D O I：

10.3389/fonc.2017.00055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This functional integration is exerted through discrete interorganelle structures known as mitochondria-associated membranes (MAMs). At these domains, ER/mitochondria physically associate to dynamically adjust metabolic demands and the response to stress stimuli. Here, we provide a focused overview of how the ER shapes the function of the mitochondria, giving a special emphasis to the significance of local signaling of the unfolded protein response at MAMs. The implications to cell fate control and the progression of cancer are also discussed.

引用

页数：7

共 61 条

[1]

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family [J].

Anelli, T ;

Alessio, M ;

Mezghrani, A ;

Simmen, T ;

Talamo, F ;

Bachi, A ;

Sitia, R .

EMBO JOURNAL, 2002, 21 (04) :835-844

[2]

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum-Mitochondria Interface (MAM) [J].

Anelli, Tiziana ;

Bergamelli, Leda ;

Margittai, Eva ;

Rimessi, Alessandro ;

Fagioli, Claudio ;

Malgaroli, Antonio ;

Pinton, Paolo ;

Ripamonti, Maddalena ;

Rizzuto, Rosario ;

Sitia, Roberto .

ANTIOXIDANTS & REDOX SIGNALING, 2012, 16 (10) :1077-1087

[3]

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity [J].

Arruda, Ana Paula ;

Pers, Benedicte M. ;

Parlakguel, Guenes ;

Gueney, Ekin ;

Inouye, Karen ;

Hotamisligil, Goekhan S. .

NATURE MEDICINE, 2014, 20 (12) :1427-1435

[4]

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress [J].

Bravo, Roberto ;

Miguel Vicencio, Jose ;

Parra, Valentina ;

Troncoso, Rodrigo ;

Pablo Munoz, Juan ;

Bui, Michael ;

Quiroga, Clara ;

Rodriguez, Andrea E. ;

Verdejo, Hugo E. ;

Ferreira, Jorge ;

Iglewski, Myriam ;

Chiong, Mario ;

Simmen, Thomas ;

Zorzano, Antonio ;

Hill, Joseph A. ;

Rothermel, Beverly A. ;

Szabadkai, Gyorgy ;

Lavandero, Sergio .

JOURNAL OF CELL SCIENCE, 2011, 124 (13) :2143-2152

[5]

Cárdenas C, 2016, CELL REP, V14, P2313, DOI [10.1016/j.celrep.2016.03.045, 10.1016/j.celrep.2016.02.030]

[6]

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria [J].

Cardenas, Cesar ;

Miller, Russell A. ;

Smith, Ian ;

Bui, Thi ;

Molgo, Jordi ;

Mueller, Marioly ;

Vais, Horia ;

Cheung, King-Ho ;

Yang, Jun ;

Parker, Ian ;

Thompson, Craig B. ;

Birnbaum, Morris J. ;

Hallows, Kenneth R. ;

Foskett, J. Kevin .

CELL, 2010, 142 (02) :270-283

[7]

BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response [J].

Castillo, Karen ;

Rojas-Rivera, Diego ;

Lisbona, Fernanda ;

Caballero, Benjamin ;

Nassif, Melissa ;

Court, Felipe A. ;

Schuck, Sebastian ;

Ibar, Consuelo ;

Walter, Peter ;

Sierralta, Jimena ;

Glavic, Alvaro ;

Hetz, Claudio .

EMBO JOURNAL, 2011, 30 (21) :4465-4478

[8]

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development [J].

Chen, HC ;

Detmer, SA ;

Ewald, AJ ;

Griffin, EE ;

Fraser, SE ;

Chan, DC .

JOURNAL OF CELL BIOLOGY, 2003, 160 (02) :189-200

[9]

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway [J].

Chen, Xi ;

Iliopoulos, Dimitrios ;

Zhang, Qing ;

Tang, Qianzi ;

Greenblatt, Matthew B. ;

Hatziapostolou, Maria ;

Lim, Elgene ;

Tam, Wai Leong ;

Ni, Min ;

Chen, Yiwen ;

Mai, Junhua ;

Shen, Haifa ;

Hu, Dorothy Z. ;

Adoro, Stanley ;

Hu, Bella ;

Song, Minkyung ;

Tan, Chen ;

Landis, Melissa D. ;

Ferrari, Mauro ;

Shin, Sandra J. ;

Brown, Myles ;

Chang, Jenny C. ;

Liu, X. Shirley ;

Glimcher, Laurie H. .

NATURE, 2014, 508 (7494) :103-+

[10]

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis [J].

Chevet, Eric ;

Hetz, Claudio ;

Samali, Afshin .

CANCER DISCOVERY, 2015, 5 (06) :586-597

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