Bone marrow derived cells in tumor angiogenesis and growth: are they the good, the bad or the evil? Preface

被引:41
作者
Shaked, Yuval [1 ]
Voest, Emile E. [2 ]
机构
[1] Technion Israel Inst Technol, Rappaport Fac Med, IL-31096 Haifa, Israel
[2] Univ Med Ctr Utrecht, Dept Med Oncol, NL-3508 Utrecht, Netherlands
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2009年 / 1796卷 / 01期
关键词
ENDOTHELIAL PROGENITOR CELLS; ANTIANGIOGENIC THERAPY; BEVACIZUMAB; RECRUITMENT; NEOVASCULARIZATION; REFRACTORINESS; METASTASIS; PRECURSORS; PACLITAXEL; CONTRIBUTE;
D O I
10.1016/j.bbcan.2009.07.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Increasing evidence implicates an important role for a variety of bone marrow derived cells (BMDCs) in tumor angiogenesis and metastatic tumor growth. These cells are derived either from the hematopoietic or mesenchymal cell lineage, and they are distinguished, in part, by the expression of the panhematopoietic marker - CD45. Some of these cell populations can colonize tumors perivascularily, and appear to promote angiogenesis and tumor cell proliferation by paracraine mechanisms, whereas others can contribute "directly" to the growth of tumor vessel capillaries or metastases. In this review we focus in particular on the role of hemangiocytes or recruited bone marrow derived circulating cells (RBCCs) in neovascularization, the contribution of VEGFR1 + hematopoietic stem cells and endothelial precursor cells in metastasis, and the involvement of myeloid derived suppressor CD11b+/Gr-1+ cells in the resistance of tumors to certain antiangiogenic drugs, e.g., VEGF blocking antibodies. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 4
页数:4
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