Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia

被引：43

作者：

Crazzolara, R

Jöhrer, K

Johnstone, RW

Greil, R

Kofler, R

Meister, B

Bernhard, D

机构：

[1] Univ Innsbruck Hosp, Dept Paediat, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Tyrolean Canc Res Inst, A-6020 Innsbruck, Austria

[3] Peter MacCallum Canc Inst, Gene Regulat Lab, Melbourne, Vic 3000, Australia

[4] Univ Innsbruck Hosp, Dept Internal Med, Lab Mol Cytol, A-6020 Innsbruck, Austria

[5] Univ Innsbruck, Inst Pathophysiol, Div Mol Pathophysiol, A-6020 Innsbruck, Austria

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 119卷 / 04期

关键词：

CXCR4; inhibitors of histone deacetylases; acute leukaemia;

D O I：

10.1046/j.1365-2141.2002.03955.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The chemokine receptor CXCR4 plays a crucial role in the survival and trafficking of leukaemia cells and requires further attention as human immunodeficiency virus type I (HIV-I) utilises CXCR4 as the major coreceptor for cellular entry. We demonstrated that inhibitors of histone deacetylases, currently being tested in clinical trials for the treatment of various tumours, extensively downregulated CXCR4 protein and mRNA levels in leukaemia cell lines and lymphoblasts from patients with childhood acute leukaemia. As a result, the ability of stromal cell-derived factor-1 to induce cellular migration was impaired. Repression of CXCR4 transcription by inhibitors of histone deacetylases might therefore represent a promising novel approach in the treatment of acute leukaemias.

引用

收藏

页码：965 / 969

页数：5

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