Early studies on DNA-based immunizations for measles virus

被引：28

作者：

Yang, K

Mustafa, F

Valsamakis, A

Santoro, JC

Griffin, DE

Robinson, HL

机构：

[1] UNIV MASSACHUSETTS, SCH MED, DEPT PATHOL, WORCESTER, MA 01655 USA

[2] JOHNS HOPKINS UNIV, SCH PUBL HLTH, DEPT MOL MICROBIOL & IMMUNOL, BALTIMORE, MD 21287 USA

来源：

VACCINE | 1997年 / 15卷 / 08期

关键词：

measles vaccine; DNA vaccines; measles hemagglutinin; measles fusion protein;

D O I：

10.1016/S0264-410X(96)00261-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemaggluttinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutralizing responses that persisted for 1 year. For both forms of hemagglutinin, the effectiveness of the raised antibody (ratio of neutralizing activity to ELISA activity) was similar. High titers of neutralizing antibody were also raised by inoculation of rabbits with the hemagglutinin and fusion glycoprotein-expressing plasmids. (C) 1997 Elsevier Science Ltd.

引用

页码：888 / 891

页数：4

共 11 条

[1] ESTABLISHMENT AND CHARACTERIZATION OF MURINE CELLS CONSTITUTIVELY EXPRESSING THE FUSION, NUCLEOPROTEIN AND MATRIX PROTEINS OF MEASLES-VIRUS [J].