Effect of adrenalectomy and exposure to corticosterone on alcohol intake in alcohol-preferring and alcohol-avoiding rat lines

被引：38

作者：

Fahlke, C

Eriksson, CJP

机构：

[1] Univ Gothenburg, Dept Psychol, SE-40530 Gothenburg, Sweden

[2] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, FIN-00101 Helsinki, Finland

来源：

ALCOHOL AND ALCOHOLISM | 2000年 / 35卷 / 02期

关键词：

D O I：

10.1093/alcalc/35.2.139

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The daily fluid intake of male rats of the alcohol-preferring (AA) and alcohol-avoiding (ANA) lines with simultaneous access to 10% (v/v) ethanol and water was determined during a baseline period (2 weeks), following adrenalectomy (1 week), and for 2 weeks following corticosterone treatment. The results showed that adrenalectomized AA rats decreased their ethanol intake compared to the sham-operated AA controls and that treatment with corticosterone restored the intake of ethanol to that observed during the baseline period. In contrast to the AA rats, there were no alterations in ethanol intake after adrenalectomy and following corticosterone replacement in the ANA rats. These results suggest that corticosterone stimulates ethanol intake in animals with pronounced high preference for ethanol.

引用

页码：139 / 144

页数：6

共 33 条

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