[I-123]beta-CIT single-photon emission tomography in DOPA-Responsive dystonia

被引：30

作者：

Naumann, M ^{[1
]}

Pirker, W ^{[1
]}

Reiners, K ^{[1
]}

Lange, K ^{[1
]}

Becker, G ^{[1
]}

机构：

[1] UNIV FREIBURG,DEPT NEUROPSYCHOL,D-7800 FREIBURG,GERMANY

来源：

MOVEMENT DISORDERS | 1997年 / 12卷 / 03期

关键词：

DOPA-responsive dystonia; SPECT; dopamine transporter; FD PET;

D O I：

10.1002/mds.870120330

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The radiotracer [I-123]beta-CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [I-123]beta-CIT single-photon emission computed tomography (SPECT) findings in a patient with DOPA-responsive dystonia (DRD). [I-123]beta-CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile-onset parkinsonism with dystonia that have a considerably poorer prognosis. [I-123]beta-CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.

引用

页码：448 / 451

页数：4

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