Tacrolimus and myocardial hypertrophy

被引：47

作者：

Nakata, Y

Yoshibayashi, M

Yonemura, T

Uemoto, S

Inomata, Y

Tanaka, K

Furusho, K

机构：

[1] Kyoto Univ, Fac Med, Kurashiki Cent Hosp, Dept Transplantat Immunol, Kurashiki, Okayama 710, Japan

[2] Kyoto Univ, Fac Med, Kurashiki Cent Hosp, Dept Pediat, Kurashiki, Okayama 710, Japan

来源：

TRANSPLANTATION | 2000年 / 69卷 / 09期

关键词：

D O I：

10.1097/00007890-200005150-00039

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tacrolimus has been used as an immunosuppressive agent in the transplantation of all solid organs. Tacrolimus-induced hypertrophic cardiomyopathy has been reported to be an unusual but serious complication. To elucidate the effects of tacrolimus on myocardial hypertrophy, we studied the relationship between the blood levels of tacrolimus and cardiac wall thickening. Our findings demonstrated that tacrolimus-induced myocardial hypertrophy correlated with tacrolimus blood levels, and that myocardial hypertrophy induced by tacrolimus was reversible. However, no patients developed clinically significant symptoms related to myocardial hypertrophy.

引用

页码：1960 / 1962

页数：3