The prevalence of hepatitis C in England and Wales

被引:38
作者
Balogun, MA
Ramsay, ME
Hesketh, LM
Andrews, N
Osborne, KP
Gay, NJ
Morgan-Capner, P
机构
[1] Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Div Immunizat, London NW9 5EQ, England
[2] Royal Preston Hosp, Preston Publ Hlth Lab, Sharoe Green Lane PR2 9HG, Lancs, England
[3] Publ Hlth Lab Serv, Stat Unit, London NW9 5EQ, England
关键词
D O I
10.1053/jinf.2002.1059
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: To estimate the background population prevalence of hepatitis C in England and Wales, observe the prevalence over time and assess the extent of infection outside of known risk groups. Methods: Sera from residual specimens from adult patients submitted to laboratories in England and Wales were tested for anti-HCV. Testing was carried out using a cost-effective pooling strategy. Results: Although the prevalence of anti-HCV was highest in 1986 (1.07%), in the multivariable analysis, prevalence did not vary significantly between the 3 periods 1986, 1991 and 1996 (P=0.14). The prevalence of infection was higher in males than in females (P=0.0013). An age-period-cohort analysis revealed a cohort effect due to a lower HCV prevalence in the most recent birth cohorts, that is, those born between the calendar years 1971-1975 and 1976-1980. Conclusions: The majority of HCV infections in England and Wales were probably acquired before 1986. Infections in younger males identified in 1996 may signify more recent acquisition by injecting drug use. (C) 2002 The British Infection Society. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:219 / 226
页数:8
相关论文
共 52 条
  • [1] HCV prevalence in pregnant women in the UK
    Ades, AE
    Parker, S
    Walker, J
    Cubitt, WD
    Jones, R
    [J]. EPIDEMIOLOGY AND INFECTION, 2000, 125 (02) : 399 - 405
  • [2] ALTER H, 1996, ANTIVIR THER S, V1, P15
  • [3] The prevalence of hepatitis C virus infection in the United States, 1988 through 1994
    Alter, MJ
    Kruszon-Moran, D
    Nainan, OV
    McQuillan, GM
    Gao, FX
    Moyer, LA
    Kaslow, RA
    Margolis, HS
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (08) : 556 - 562
  • [4] EPIDEMIOLOGY OF HEPATITIS-C IN THE WEST
    ALTER, MJ
    [J]. SEMINARS IN LIVER DISEASE, 1995, 15 (01) : 5 - 14
  • [5] Hepatitis C antibody prevalence in blood donors in different governorates in Egypt
    Arthur, RR
    Hassan, NF
    Abdallah, MY
    ElSharkawy, MS
    Saad, MD
    Hackbart, BG
    Imam, IZ
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1997, 91 (03) : 271 - 274
  • [6] Acute hepatitis B infection in England and Wales: 1985-96
    Balogun, MA
    Ramsay, ME
    Fairley, CK
    Collins, M
    Heptonstall, J
    [J]. EPIDEMIOLOGY AND INFECTION, 1999, 122 (01) : 125 - 131
  • [7] The prevalence and genetic diversity of hepatitis C infection in antenatal clinic attenders in two regions of England
    Balogun, MA
    Ramsay, ME
    Parry, JV
    Donovan, L
    Andrews, NJ
    Newham, JA
    Cliffe, S
    Harris, KA
    Teo, CG
    [J]. EPIDEMIOLOGY AND INFECTION, 2000, 125 (03) : 705 - 712
  • [8] PREVALENCE OF HEPATITIS-C VIRUS-ANTIBODY AMONG HEALTHY BLOOD-DONORS AND NON-A, NON-B HEPATITIS PATIENTS IN THAILAND
    BOONMAR, S
    POJANAGAROON, B
    WATANABE, Y
    TANAKA, Y
    SAITO, I
    MIYAMURA, T
    [J]. JAPANESE JOURNAL OF MEDICAL SCIENCE & BIOLOGY, 1990, 43 (02): : 29 - 36
  • [9] THE MANAGEMENT OF CHRONIC HEPATITIS-C VIRUS-INFECTION
    BOOTH, JCL
    BROWN, JL
    THOMAS, HC
    [J]. GUT, 1995, 37 (04) : 449 - 454
  • [10] Brind AM, 1996, QJM-INT J MED, V89, P291