Growth factor treatment of demyelinating disease: at last, a leap into the light

被引：31

作者：

Ransohoff, RM

Howe, CL

Rodriguez, M

机构：

[1] Cleveland Clin Fdn, Dept Neurosci, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Dept Neurol, Cleveland, OH 44195 USA

[3] Mayo Clin, Dept Immunol, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 11期

关键词：

D O I：

10.1016/S1471-4906(02)02321-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Researchers seeking treatments for multiple sclerosis (MS) have long dreamed of using neurotrophic factors to enhance remyelination. Previous attempts to apply trophic support for oligodendrocytes in experimental demyelination uniformly produced complicated outcomes that reflected unexpected effects on immune or inflammatory responses and could be interpreted only with caution. Now, two recent publications have demonstrated convincingly that cytokines of the interleukin (IL)-6 superfamily can ameliorate experimental autoimmune encephalomyelitis and promote oligodendrocyte survival, without demonstrable effect on inflammation or immune responses.

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页码：512 / 516

页数：5

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