Genetics of rheumatic disease

被引：22

作者：

Clarke, Alex ^{[1
]}

Vyse, Timothy J. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Sect Mol Genet & Rheumatol, Hammersmith Hosp, London W12 0NN, England

来源：

ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 05期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; COPY-NUMBER VARIATION; NF-KAPPA-B; COLLAGEN-INDUCED ARTHRITIS; ANKYLOSING-SPONDYLITIS; FUNCTIONAL VARIANTS; FRENCH POPULATION; NO ASSOCIATION; RISK-FACTOR;

D O I：

10.1186/ar2781

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Many of the chronic inflammatory and degenerative disorders that present to clinical rheumatologists have a complex genetic aetiology. Over the past decade a dramatic improvement in technology and methodology has accelerated the pace of gene discovery in complex disorders in an exponential fashion. In this review, we focus on rheumatoid arthritis, systemic lupus erythematosus and ankylosing spondylitis and describe some of the recently described genes that underlie these conditions and the extent to which they overlap. The next decade will witness a full account of the main disease susceptibility genes in these diseases and progress in establishing the molecular basis by which genetic variation contributes to pathogenesis.

引用

页数：9

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