Self-assembled oligonucleotide-polyester dendrimers

被引：27

作者：

Goh, SL

Francis, MB

Fréchet, JMJ

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] EO Lawrence Berkeley Natl Labs, Div Mat Sci, Berkeley, CA 94720 USA

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 24期

关键词：

D O I：

10.1039/b209029e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new approach to the controlled synthesis of multicomponent dendrimers is presented, in which three oligonucleotide-dendron conjugates were synthesized using solid phase techniques and hybridized to create a second generation polyester dendrimer with DNA as a core and bearing two types of peripheral functional groups.

引用

收藏

页码：2954 / 2955

页数：2

相关论文

共 16 条

[1] Light-harvesting dendrimers [J].

Adronov, A ;

Fréchet, JMJ .

CHEMICAL COMMUNICATIONS, 2000, (18) :1701-1710

[2] Dendrimers and supramolecular chemistry [J].

Fréchet, JMJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :4782-4787

[3] Synthesis and surface functionalization of aliphatic polyether dendrons [J].

Grayson, SM ;

Fréchet, JMJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (42) :10335-10344

[4] Double-stage convergent approach for the synthesis of functionalized dendritic aliphatic polyesters based on 2,2-bis(hydroxymethyl)propionic acid [J].

Ihre, H ;

Hult, A ;

Frechet, JMJ ;

Gitsov, I .

MACROMOLECULES, 1998, 31 (13) :4061-4068

[5] Polyester dendritic systems for drug delivery applications:: Design, synthesis, and characterization [J].

Ihre, HR ;

De Jesüs, OLP ;

Szoka, FC ;

Fréchet, JMJ .

BIOCONJUGATE CHEMISTRY, 2002, 13 (03) :443-452

[6] Applications of dendrimers in bio-organic chemistry [J].

Kim, Y ;

Zimmerman, SC .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (06) :733-742

[7]

Modrakowski C, 2001, SYNTHESIS-STUTTGART, P2143

[8]

Niemeyer CM, 2001, ANGEW CHEM INT EDIT, V40, P4128, DOI 10.1002/1521-3773(20011119)40:22<4128::AID-ANIE4128>3.0.CO

[9]

2-S

[10] Oligonucleotide dendrimers: stable nano-structures [J].

Shchepinov, MS ;

Mir, KU ;

Elder, JK ;

Frank-Kamenetskii, MD ;

Southern, EM .

NUCLEIC ACIDS RESEARCH, 1999, 27 (15) :3035-3041