A genetic linkage map of the baboon (Papio hamadryas) genome based on human microsatellite polymorphisms

被引：141

作者：

Rogers, J

Mahaney, MC

Witte, SM

Nair, S

Newman, D

Wedel, S

Rodriguez, LA

Rice, KS

Slifer, SH

Perelygin, A

Slifer, M

Palladino-Negro, P

Newman, T

Chambers, K

Joslyn, G

Parry, P

Morin, PA

机构：

[1] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78227 USA

[2] SW Reg Primate Res Ctr, San Antonio, TX 78245 USA

[3] Axys Pharmaceut Inc, La Jolla, CA 92037 USA

来源：

GENOMICS | 2000年 / 67卷 / 03期

关键词：

D O I：

10.1006/geno.2000.6245

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A first-generation genetic linkage map of the baboon (Papio hamadryas) genome was developed for use in biomedical and evolutionary genetics. Pedigreed baboons (n = 694) were selected from the breeding colony maintained by the Southwest Foundation for Biomedical Research. To facilitate comparison with the human genome, the baboon linkage map consists primarily of human microsatellite loci amplified using published human PCR primers. Genotypes for 325 human microsatellites and 6 novel baboon microsatellites were used in linkage analyses performed with the MultiMap expert system, The resulting sex-averaged meiotic recombination map covers all 20 baboon autosomes, with average spacing among loci of 7.2 cM. Direct comparison among homologous (orthologous) loci reveals that, for 7 human autosomes, locus order is conserved between humans and baboons. For the other 15 autosomes, one or more rearrangements distinguish the two genomes. The total centimorgan distances among homologous markers are 28.0% longer in the human genome than in the baboon, suggesting that rates of recombination may be higher in humans. This baboon linkage map is the first reported for any nonhuman primate species and creates opportunities for mapping quantitative trait loci in baboons, as well as for comparative evolutionary analyses of genome structure. (C) 2000 Academic Press.

引用

页码：237 / 247

页数：11

共 49 条

[1] Multipoint quantitative-trait linkage analysis in general pedigrees [J].

Almasy, L ;

Blangero, J .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1198-1211

[2] Behavior predicts genetic structure in a wild primate group [J].

Altmann, J ;

Alberts, SC ;

Haines, SA ;

Dubach, J ;

Muruthi, P ;

Coote, T ;

Geffen, E ;

Cheesman, DJ ;

Mututua, RS ;

Saiyalel, SN ;

Wayne, RK ;

Lacy, RC ;

Bruford, MW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) :5797-5801

[3] Comparative genome organization of vertebrates [J].

Andersson, L ;

Archibald, A ;

Ashburner, M ;

Audun, S ;

Barendse, W ;

Bitgood, J ;

Bottema, C ;

Broad, T ;

Brown, S ;

Burt, D ;

Charlier, C ;

Copeland, N ;

Davis, S ;

Davisson, M ;

Edwards, J ;

Eggen, A ;

Elgar, G ;

Eppig, JT ;

Franklin, I ;

Grewe, P ;

Gill, T ;

Graves, JAM ;

Hawken, R ;

Hetzel, J ;

Hilyard, A ;

Jacob, H ;

Jaswinska, L ;

Jenkins, N ;

Kunz, H ;

Levan, G ;

Lie, O ;

Lyons, L ;

Maccarone, P ;

Mellersh, C ;

Montgomery, G ;

Moore, S ;

Moran, C ;

Morizot, D ;

Neff, M ;

Nicholas, F ;

OBrien, S ;

Parsons, Y ;

Peters, J ;

Postlethwait, J ;

Raymond, M ;

Rothschild, M ;

Schook, L ;

Sugimoto, Y ;

Szpirer, C ;

Tate, M .

MAMMALIAN GENOME, 1996, 7 (10) :717-734

[4] Baboon/human homologies examined by spectral karyotyping (SKY): a visual comparison [J].

Best, RG ;

Diamond, D ;

Crawford, E ;

Grass, FS ;

Janish, C ;

Lear, TL ;

Soenksen, D ;

Szalay, AA ;

Moore, CM .

CYTOGENETICS AND CELL GENETICS, 1998, 82 (1-2) :83-87

[5]

CAMBEFORT Y, 1976, ANN GENET-PARIS, V19, P5

[6] Human microsatellites applicable for analysis of genetic variation in apes and old world monkeys [J].

Coote, T ;

Bruford, MW .

JOURNAL OF HEREDITY, 1996, 87 (05) :406-410

[7] A second-generation linkage map of the sheep genome [J].

de Gortari, MJ ;

Freking, BA ;

Cuthbertson, RP ;

Kappes, SM ;

Keele, JW ;

Stone, RT ;

Leymaster, KA ;

Dodds, KG ;

Crawford, AM ;

Beattie, CW .

MAMMALIAN GENOME, 1998, 9 (03) :204-209

[8] A GENETIC-MAP OF THE MOUSE WITH 4,006 SIMPLE SEQUENCE LENGTH POLYMORPHISMS [J].

DIETRICH, WF ;

MILLER, JC ;

STEEN, RG ;

MERCHANT, M ;

DAMRON, D ;

NAHF, R ;

GROSS, A ;

JOYCE, DC ;

WESSEL, M ;

DREDGE, RD ;

MARQUIS, A ;

STEIN, LD ;

GOODMAN, N ;

PAGE, DC ;

LANDER, ES .

NATURE GENETICS, 1994, 7 (02) :220-245

[9] TOUCHDOWN PCR TO CIRCUMVENT SPURIOUS PRIMING DURING GENE AMPLIFICATION [J].

DON, RH ;

COX, PT ;

WAINWRIGHT, BJ ;

BAKER, K ;

MATTICK, JS .

NUCLEIC ACIDS RESEARCH, 1991, 19 (14) :4008-4008

[10] COMPARISON OF THE KARYOTYPES OF 4 CERCOPITHECOIDAE - PAPIO-PAPIO, P-ANUBIS, MACACA-MULATTA, AND M-FASCICULARIS [J].

DUTRILLAUX, B ;

BIEMONT, MC ;

VIEGASPEQUIGNOT, E ;

LAURENT, C .

CYTOGENETICS AND CELL GENETICS, 1979, 23 (1-2) :77-83

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