In vivo-applied functional RNAs as tools in proteomics and genomics research

被引：54

作者：

Famulok, M

Verma, S

机构：

[1] Univ Bonn, Inst Biochem, D-53121 Bonn, Germany

[2] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

TRENDS IN BIOTECHNOLOGY | 2002年 / 20卷 / 11期

关键词：

D O I：

10.1016/S0167-7799(02)02063-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Non-natural, functional RNA molecules, such as short interfering (si) RNAs, aptazymes, maxizymes and intramers, allow modulation of gene function at the mRNA or protein level. This review discusses recent advances made in the expression and application of these functional RNAs and illustrates how engineered, intarcellularly active RNAs can serve as promising tools for understanding the function of genes and their protein products or as potential therapeutic agents.

引用

收藏

页码：462 / 466

页数：5

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