A simple and selective method for the separation of Cu radioisotopes from nickel

被引:14
作者
Fan, Xianfeng [1 ]
Parker, David J. [1 ]
Smith, Mike D. [1 ]
Ingram, Andy [1 ]
Yang, Zhufang [1 ]
Seville, Jonathan P. K. [1 ]
机构
[1] Univ Birmingham, Sch Phys & Astron, Birmingham B15 2TT, W Midlands, England
关键词
copper radioisotopes; nickel; purification; ion exchange; Chelex-100;
D O I
10.1016/j.nucmedbio.2005.08.001
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Separation of copper radioisotopes from a nickel target is normally performed using solvent extraction or anion exchange rather than using cationic exchange. A commonly held opinion is that cationic exchangers have very similar thermodynamic complexation constants for metallic ions with identical charges, therefore making the separation very difficult or impossible. The results presented in this article indicate that the selectivity of Chelex-100 (a cationic ion exchanger) for Cu radioisotope and Ni ions not only depends on the thermodynamic complexation constant in the resin but also markedly varies with the concentration of mobile H+. In our developed method, separation of copper radioisotopes from a nickel target was fulfilled in a column filled with Chelex-100 via controlling the HNO3 concentration of the eluent, and the separation is much more effective, simple and economical in comparison with the common method of anion exchange. For an irradiated nickel target with 650 mg Ni, after separation, the loss of Cu radioisotopes in the nickel portion was reduced from 30% to 0.33% of the total initial radioactivity and the nickel mixed into the radioactive products was reduced from 9.5 to 0.5 mg. This significant improvement will make subsequent labeling much easier and reduce consumption of chelating agents and other chemicals during labeling. If the labeled agent is used in human medical applications, the developed method will significantly decrease the uptake of Ni and chelating agents by patients, therefore reducing both the stress on human body associated with clearing the chemicals from blood and tissue and the risk of various types of acute and chronic disorder due to exposure to Ni. (c) 2006 Published by Elsevier Inc.
引用
收藏
页码:939 / 944
页数:6
相关论文
共 32 条
[1]   Adsorption behaviour of metal ions on hydroximate resins [J].
Ahuja, M ;
Rai, AK ;
Mathur, PN .
TALANTA, 1996, 43 (11) :1955-1963
[2]   Removal and recovery of nickel(II) from aqueous solution by loofa sponge-immobilized biomass of Chlorella sorokiniana:: characterization studies [J].
Akhtar, N ;
Iqbal, J ;
Iqbal, M .
JOURNAL OF HAZARDOUS MATERIALS, 2004, 108 (1-2) :85-94
[3]   Copper radionuclides and radiopharmaceuticals in nuclear medicine [J].
Blower, PJ ;
Lewis, JS ;
Zweit, J .
NUCLEAR MEDICINE AND BIOLOGY, 1996, 23 (08) :957-980
[4]   TOXICITY AND CARCINOGENICITY OF NICKEL COMPOUNDS [J].
COOGAN, TP ;
LATTA, DM ;
SNOW, ET ;
COSTA, M .
CRC CRITICAL REVIEWS IN TOXICOLOGY, 1989, 19 (04) :341-384
[5]   The mechanisms of nickel uptake by rat primary hepatocyte cultures: role of calcium channels [J].
Funakoshi, T ;
Inoue, T ;
Shimada, H ;
Kojima, S .
TOXICOLOGY, 1997, 124 (01) :21-26
[6]   Separation of no-carrier-added 64Cu from a proton irradiated 64Ni enriched nickel target [J].
Hou, XL ;
Jacobsen, U ;
Jorgensen, JC .
APPLIED RADIATION AND ISOTOPES, 2002, 57 (06) :773-777
[7]  
INT AGCY RES CANC, 1990, IARC MONOG EVAL CARC, V49, P257
[8]   The in vivo behavior of copper-64-labeled azamacrocyclic complexes [J].
Jones-Wilson, TM ;
Deal, KA ;
Anderson, CJ ;
McCarthy, DW ;
Kovacs, Z ;
Motekaitis, RJ ;
Sherry, AD ;
Martell, AE ;
Welch, MJ .
NUCLEAR MEDICINE AND BIOLOGY, 1998, 25 (06) :523-530
[9]   Nickel carcinogenesis [J].
Kasprzak, Kazimierz S. ;
Sunderman, F. William, Jr. ;
Salnikow, Konstantin .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2003, 533 (1-2) :67-97
[10]   ANION EXCHANGE STUDIES .6. THE DIVALENT TRANSITION ELEMENTS MANGANESE TO ZINC IN HYDROCHLORIC ACID [J].
KRAUS, KA ;
MOORE, GE .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1953, 75 (06) :1460-1462