Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application

被引：177

作者：

Merino-Gonzalez, Consuelo ^{[1
]}

Zuniga, Felipe A. ^{[1
]}

Escudero, Carlos ^{[2
,3
]}

Ormazabal, Valeska ^{[4
]}

Reyes, Camila ^{[1
]}

Nova-Lamperti, Estefana ^{[5
]}

Salomon, Carlos ^{[6
]}

Aguayo, Claudio ^{[1
,3
]}

机构：

[1] Univ Concepcion, Fac Pharm, Dept Clin Biochem & Immunol, Concepcion, Chile

[2] Univ Bio Bio, Dept Basic Sci, Vasc Physiol Lab, Grp Invest Tumor Angiogenesis GIANT, Chillan, Chile

[3] Grp Res & Innovat Vasc Hlth GRIVAS Hlth, Chillan, Chile

[4] Univ Concepcion, Fac Biol Sci, Dept Physiopathol, Concepcion, Chile

[5] Kings Coll London, MRC, Ctr Transplantat, London, England

[6] Univ Queensland, Clin Res Ctr, Royal Brisbane & Womens Hosp, Exosome Biol Lab,Ctr Clin Diagnost, Brisbane, Qld, Australia

来源：

FRONTIERS IN PHYSIOLOGY | 2016年 / 7卷

关键词：

mesenchymal stem cell; extracellular vesicles; angiogenesis; EXOSOME-MEDIATED TRANSFER; STROMAL CELLS; ENDOTHELIAL-CELLS; IN-VIVO; GROWTH-FACTOR; PARACRINE MECHANISMS; VASCULAR DEVELOPMENT; BREAST-CANCER; TISSUE; MICROVESICLES;

D O I：

10.3389/fphys.2016.00024

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Mesenchymal stem cells (MSCs) are adult multipotent stem cells that are able to differentiate into multiple specialized cell types including osteocytes, adipocytes, and chondrocytes. MSCs exert different functions in the body and have recently been predicted to have a major clinical/therapeutic potential. However, the mechanisms of self-renewal and tissue regeneration are not completely understood. It has been shown that the biological effect depends mainly on its paracrine action. Furthermore, it has been reported that the secretion of soluble factors and the release of extracellular vesicles, such as exosomes, could mediate the cellular communication to induce cell-differentiation/self-renewal. This review provides an overview of MSC-derived exosomes in promoting angiogenicity and of the clinical relevance in a therapeutic approach.

引用

页数：9

共 95 条

[1]

Molecular regulation of angiogenesis and lymphangiogenesis [J].

Adams, Ralf H. ;

Alitalo, Kari .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (06) :464-478

[2]

Endothelium Trans Differentiated from Wharton's Jelly Mesenchymal Cells Promote Tissue Regeneration: Potential Role of Soluble Pro-Angiogenic Factors [J].

Aguilera, Valeria ;

Briceno, Luis ;

Contreras, Hector ;

Lamperti, Liliana ;

Sepulveda, Esperanza ;

Diaz-Perez, Francisca ;

Leon, Marcelo ;

Veas, Carlos ;

Maura, Rafael ;

Roberto Toledo, Jorge ;

Fernandez, Paulina ;

Covarrubias, Ambart ;

Andres Zuniga, Felipe ;

Radojkovic, Claudia ;

Escudero, Carlos ;

Aguayo, Claudio .

PLOS ONE, 2014, 9 (11)

[3]

METASTASIS Exosomes drive premetastatic niche formation [J].

Alderton, Gemma K. .

NATURE REVIEWS CANCER, 2012, 12 (07) :447-447

[4]

Term amniotic membrane is a high throughput source for multipotent mesenchymal stem cells with the ability to differentiate into endothelial cells in vitro [J].

Alviano, Francesco ;

Fossati, Valentina ;

Marchionni, Cosetta ;

Arpinati, Mario ;

Bonsi, Laura ;

Franchina, Michele ;

Lanzoni, Giacomo ;

Cantoni, Silvia ;

Cavallini, Claudia ;

Bianchi, Francesca ;

Tazzari, Pier Luigi ;

Pasquinelli, Gianandrea ;

Foroni, Laura ;

Ventura, Carlo ;

Grossi, Alberto ;

Bagnara, Gian Paolo .

BMC DEVELOPMENTAL BIOLOGY, 2007, 7

[5]

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species [J].

Baglio, Serena Rubina ;

Rooijers, Koos ;

Koppers-Lalic, Danijela ;

Verweij, Frederik J. ;

Lanzon, M. Perez ;

Zini, Nicoletta ;

Naaijkens, Benno ;

Perut, Francesca ;

Niessen, Hans W. M. ;

Baldini, Nicola ;

Pegtel, D. Michiel .

STEM CELL RESEARCH & THERAPY, 2015, 6

[6]

Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilinelage differentiation [J].

Battula, Venkata Lokesh ;

Bareiss, Petra M. ;

Treml, Sabrina ;

Conrad, Sabine ;

Albert, Ingrid ;

Hojak, Sigrid ;

Abele, Harald ;

Schewe, Bernhard ;

Just, Lothar ;

Skutella, Thomas ;

Buehring, Hans-Jorg .

DIFFERENTIATION, 2007, 75 (04) :279-291

[7]

Flow control in our vessels: vascular valves make sure there is no way back [J].

Bazigou, Eleni ;

Makinen, Taija .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (06) :1055-1066

[8]

Bruno S., 2012, PLOS ONE, V7, DOI DOI 10.1371/journal.pone.0033115

[9]

Exosomes/microvesicles as a mechanism of cell-to-cell communication [J].

Camussi, Giovanni ;

Deregibus, Maria C. ;

Bruno, Stefania ;

Cantaluppi, Vincenzo ;

Biancone, Luigi .

KIDNEY INTERNATIONAL, 2010, 78 (09) :838-848

[10]

Microvesicles Derived From Endothelial Progenitor Cells Enhance Neoangiogenesis of Human Pancreatic Islets [J].

Cantaluppi, Vincenzo ;

Biancone, Luigi ;

Figliolini, Federico ;

Beltramo, Silvia ;

Medica, Davide ;

Deregibus, Maria Chiara ;

Galimi, Francesco ;

Romagnoli, Renato ;

Salizzoni, Mauro ;

Tetta, Ciro ;

Segoloni, Giuseppe Paolo ;

Camussi, Giovanni .

CELL TRANSPLANTATION, 2012, 21 (06) :1305-1320

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