Application of a new chiral stationary phase containing the glycopeptide antibiotic A-40,926 in the direct chromatographic resolution of β-amino acids

被引：58

作者：

D'Acquarica, I

Gasparrini, F

Misiti, D

Zappia, G

Cimarelli, C

Palmieri, G

Carotti, A

Cellamare, S

Villani, C

机构：

[1] Univ Roma La Sapienza, Dip Chim & Tecnol Sostanze Biologicamente Att, I-00185 Rome, Italy

[2] Dipartimento Sci Chim, I-62032 Camerino, Italy

[3] Dipartimento Farmacochim, I-70126 Bari, Italy

[4] Dip Sci Farmaco, I-66013 Chieti, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)00198-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new enantioselective HPLC procedure for the direct resolution of p-amino acids is described, based on the use of a new chiral stationary phase (CSP) containing the macrocyclic glycopeptide antibiotic A-40,926, structurally related to teicoplanin. covalently bonded to silica gel microparticles. The new CSP shows higher enantioselectivity and broader applicability in this field compared to the parent teicoplanin phase. The potential for semi-preparative separations on the A-40,926-CSP is demonstrated for a selected cyclic beta-amino acid. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：2375 / 2385

页数：11

共 47 条

[1] LEWIS ACID-PROMOTED 1,4-ADDITION TO CHIRAL IMIDE DERIVATIVES IN THE SYNTHESIS OF BETA-AMINO ACIDS [J].