Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1

被引:129
作者
McMahon, Francis J. [1 ]
Akula, Nirmala [1 ]
Schulze, Thomas G. [1 ,2 ]
Muglia, Pierandrea [3 ,4 ]
Tozzi, Federica [3 ]
Detera-Wadleigh, Sevilla D. [1 ]
Steele, C. J. M. [1 ]
Breuer, Rene [2 ]
Strohmaier, Jana [2 ]
Wendland, Jens R. [1 ]
Mattheisen, Manuel [5 ,6 ,7 ]
Muehleisen, Thomas W. [5 ,6 ]
Maier, Wolfgang [8 ]
Noethen, Markus M. [5 ,6 ]
Cichon, Sven [5 ,6 ]
Farmer, Anne [9 ]
Vincent, John B. [4 ]
Holsboer, Florian [10 ]
Preisig, Martin [11 ,12 ]
Rietschel, Marcella [2 ,6 ]
机构
[1] NIMH, Unit Genet Basis Mood & Anxiety Disorders, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
[2] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-6800 Mannheim, Germany
[3] GlaxoSmithKline, Res & Dev, Neurosci Ctr Excellence Drug Discovery, Verona, Italy
[4] Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, Toronto, ON, Canada
[5] Univ Bonn, Dept Genom, Life & Brain Ctr, D-5300 Bonn, Germany
[6] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany
[7] Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-5300 Bonn, Germany
[8] Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany
[9] Kings Coll London, Inst Psychiat, London WC2R 2LS, England
[10] Max Planck Inst Psychiat, D-80804 Munich, Germany
[11] Univ Hosp Ctr, Lausanne, Switzerland
[12] Univ Lausanne, Dept Psychiat, Lausanne, Switzerland
基金
瑞士国家科学基金会;
关键词
BIPOLAR DISORDER; LINKAGE;
D O I
10.1038/ng.523
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genetic association studies have had limited success in robustly identifying risk loci. We performed a meta-analysis of five case-control cohorts for major mood disorder, including over 13,600 individuals genotyped on high-density SNP arrays. We identified SNPs at 3p21.1 associated with major mood disorders (rs2251219, P = 3.63 x 10(-8); odds ratio = 0.87; 95% confidence interval, 0.83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD.
引用
收藏
页码:128 / U52
页数:5
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