Toxicodynamics of Itraconazole: Implications for Therapeutic Drug Monitoring

被引:106
作者
Lestner, Jodi M. [1 ]
Roberts, Steven A. [2 ]
Moore, Caroline B. [1 ,3 ]
Howard, Susan J. [1 ,3 ]
Denning, David W. [1 ]
Hope, William W. [1 ]
机构
[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Univ Hosp S Manchester,NHS Fdn Trust, NIHR Translat Res Facil Resp Med, Manchester M13 9PT, Lancs, England
[2] Univ Manchester, Hlth Methodol Res Grp, Manchester M13 9PT, Lancs, England
[3] Univ S Manchester Hosp, NHS Fdn Trust, Reg Mycol Lab, Manchester M20 8LR, Lancs, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
RANDOMIZED CONTROLLED-TRIAL; ORAL ANTIFUNGAL TREATMENT; FUNGAL SENSITIZATION; SEVERE ASTHMA; ASPERGILLOSIS;
D O I
10.1086/605499
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
We explored concentration-toxicity relationships for itraconazole among 216 patients. Logistic regression revealed a progressive increase in the probability of toxicity with increasing concentrations of itraconazole. Classification and regression tree analysis suggested that 17.1 mg/L of itraconazole (measured using a bioassay) was the concentration level at which the population of patients was separated into 2 groups, each with a high and a low probability of toxicity.
引用
收藏
页码:928 / 930
页数:3
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