Toxicodynamics of Itraconazole: Implications for Therapeutic Drug Monitoring

被引：106

作者：

Lestner, Jodi M. ^{[1
]}

Roberts, Steven A. ^{[2
]}

Moore, Caroline B. ^{[1
,3
]}

Howard, Susan J. ^{[1
,3
]}

Denning, David W. ^{[1
]}

Hope, William W. ^{[1
]}

机构：

[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Univ Hosp S Manchester,NHS Fdn Trust, NIHR Translat Res Facil Resp Med, Manchester M13 9PT, Lancs, England

[2] Univ Manchester, Hlth Methodol Res Grp, Manchester M13 9PT, Lancs, England

[3] Univ S Manchester Hosp, NHS Fdn Trust, Reg Mycol Lab, Manchester M20 8LR, Lancs, England

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 06期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

RANDOMIZED CONTROLLED-TRIAL; ORAL ANTIFUNGAL TREATMENT; FUNGAL SENSITIZATION; SEVERE ASTHMA; ASPERGILLOSIS;

D O I：

10.1086/605499

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We explored concentration-toxicity relationships for itraconazole among 216 patients. Logistic regression revealed a progressive increase in the probability of toxicity with increasing concentrations of itraconazole. Classification and regression tree analysis suggested that 17.1 mg/L of itraconazole (measured using a bioassay) was the concentration level at which the population of patients was separated into 2 groups, each with a high and a low probability of toxicity.

引用

收藏

页码：928 / 930

页数：3

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